BOS-172722-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBOS-172722Cat.No.:HY-112162CASNo.:1578245-44-9分?式:C??H??N?O分?量:446.55作?靶點(diǎn):Mps1作?通路:CellCycle/DNADamage;Cytoskeleton儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)1MHCl:65mg/mL(145.56mM;ultrasonicandadjustpHto2withHCl)DMSO:5mg/mL(11.20mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.2394mL11.1970mL22.3939mL5mM0.4479mL2.2394mL4.4788mL10mM0.2239mL1.1197mL2.2394mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性BOS-172722單極紡錘體1(MPS1)檢查點(diǎn)的抑制劑，其對MPS1(1mMATP)和P-MPS1的IC50值分別為11nM和63nM。BOS-172722可?于多種乳腺癌的研究。IC50&Target2nM(MPS1)[1].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體外研究BOS-172722isaninhibitorofmonopolarspindle1(MPS1)checkpointwithanIC50of2nM.BOS-172722alsohaspotentialforthetreatmentofvariousformsofbreastcancer[1].體內(nèi)研究BOS-172722showsexcellentPKinmouse,rat,anddog[1].BOS-172722(50mg/kg)resultsinanincreasedsuppressionofMPS1autophosphorylationat6and24h[1].AnimalModel:Dog[2].Dosage:1mg/kg(iv),5mg/kg(po)(PharmacokineticAnalysis).Administration:IVandPO.Result:T1/2=12h,Cmaxpo=7770nmol/L,AUCpo=147035h*nmol/L.REFERENCES[1].ARYLSULFONOHYDRAZIDES.WO2014037750A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>