Zidebactam-WCK-5107-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEZidebactamCat.No.:HY-120859CASNo.:1436861-97-0Synonyms:WCK-5107分?式:C??H??N?O?S分?量:391.4作?靶點(diǎn):Bacterial作?通路:Anti-infection儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:250mg/mL(638.73mM;Needultrasonic)H2O:50mg/mL(127.75mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.5549mL12.7747mL25.5493mL5mM0.5110mL2.5549mL5.1099mL10mM0.2555mL1.2775mL2.5549mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請?jiān)?個?內(nèi)使?，-20°C儲存時，請?jiān)?個?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥1.98mg/mL(5.06mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(5.31mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(5.31mM);Clearsolution4.請依序添加每種溶劑：PBSSolubility:100mg/mL(255.49mM);Clearsolution;Needultrasonicandwarmingandheatto60°CBIOLOGICALACTIVITY?物活性Zidebactam(WCK-5107)?種有效的β-內(nèi)酰胺酶抑制劑[1]。Zidebactam也?種霉素結(jié)合蛋?2(PBP2)抑制劑，其IC50為0.26μg/ml[2]。IC50&TargetIC50:0.26μg/mL(P.aeruginosaPAO1PBP2)[2]體外研究Zidebactam(WCK-5107)inhibitsWTEnterobacteriaceaewithaMIC50of0.25?mg/L.ZidebactamaloneexhibitsvariableactivitywhentestedagainstE.coli(MIC50/900.12/0.12?mg/L)andEnterobacterspp.(MIC50/900.12/0.25?mg/L)[1].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?MicrobiolSpectr.2022Feb23;10(1):e0267821.?AntimicrobAgentsChemother.2021Nov22;AAC0167621.?Antibiotics(Basel).2021,10(11),1341.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SaderHS,etal.WCK5222(cefepime/zidebactam)antimicrobialactivitytestedagainstGram-negativeorganismsproducingclinicallyrelevantβ-lactamases.JAntimicrobChemother.2017Jun1;72(6):1696-1703.[2].MoyaB,etal.WCK5107(Zidebactam)andWCK5153AreNovelInhibitorsofPBP2ShowingPotent"β-LactamEnhancer"ActivityagainstPseudomonasaeruginosa,IncludingMultidrug-ResistantMetallo-β-Lactamase-ProducingHigh-RiskClones.AntimicrobAgentsChemMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forr