合肥地區(qū)某三級醫(yī)院碳青霉烯耐藥肺炎克雷伯菌血流感染危險(xiǎn)因素分析_第1頁
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合肥地區(qū)某三級醫(yī)院碳青霉烯耐藥肺炎克雷伯菌血流感染危險(xiǎn)因素分析摘要

目的:本研究旨在分析合肥地區(qū)某三級醫(yī)院碳青霉烯耐藥肺炎克雷伯菌血流感染的危險(xiǎn)因素,為臨床醫(yī)生提供指導(dǎo)。

方法:回顧性分析2017年1月至2020年12月間碳青霉烯耐藥肺炎克雷伯菌血流感染的患者資料,采用單因素與多因素Logistic回歸分析,多因素分析包括性別、年齡、基礎(chǔ)疾病、留置導(dǎo)管、呼吸機(jī)使用等因素。

結(jié)果:共納入261例患者,其中男性157例(60.2%),女性104例(39.8%)。單因素Logistic回歸分析顯示,留置導(dǎo)管、呼吸機(jī)使用、消化道功能損傷、膽囊疾病、輸血等因素是血流感染的危險(xiǎn)因素(P<0.05);多因素Logistic回歸分析顯示,留置導(dǎo)管、呼吸機(jī)使用是血流感染的獨(dú)立危險(xiǎn)因素(P<0.05)。

結(jié)論:留置導(dǎo)管和呼吸機(jī)使用是該醫(yī)院碳青霉烯耐藥肺炎克雷伯菌血流感染的獨(dú)立危險(xiǎn)因素,應(yīng)采取針對性措施,降低血流感染率。

關(guān)鍵詞:碳青霉烯耐藥肺炎克雷伯菌,血流感染,留置導(dǎo)管,呼吸機(jī)使用,多因素分析

Abstract

Objective:Thisstudyaimedtoanalyzetheriskfactorsofcarbapenem-resistantKlebsiellapneumoniaebloodstreaminfectionsinatertiaryhospitalinHefei,providingguidanceforclinicians.

Methods:Weretrospectivelyanalyzedthedataofpatientswithcarbapenem-resistantKlebsiellapneumoniaebloodstreaminfectionsbetweenJanuary2017andDecember2020.Univariateandmultivariatelogisticregressionanalysiswereperformed,andthemultivariateanalysisincludedfactorssuchasgender,age,underlyingdiseases,indwellingcatheter,andmechanicalventilation.

Results:Atotalof261patientswereincluded,including157males(60.2%)and104females(39.8%).Univariatelogisticregressionanalysisshowedthatindwellingcatheter,mechanicalventilation,digestivefunctioninjury,gallbladderdisease,transfusion,andotherfactorswereriskfactorsforbloodstreaminfections(P<0.05).Multivariatelogisticregressionanalysisshowedthatindwellingcatheterandmechanicalventilationwereindependentriskfactorsforbloodstreaminfections(P<0.05).

Conclusion:Indwellingcatheterandmechanicalventilationareindependentriskfactorsforcarbapenem-resistantKlebsiellapneumoniaebloodstreaminfectionsinthishospital.Targetedmeasuresshouldbetakentoreducetherateofbloodstreaminfections.

Keywords:Carbapenem-resistantKlebsiellapneumoniae,bloodstreaminfection,indwellingcatheter,mechanicalventilation,multivariateanalysiCarbapenem-resistantKlebsiellapneumoniae(CRKP)bloodstreaminfectionsareasignificantconcerninhospitalsworldwide,anditisessentialtoidentifyriskfactorsthatcontributetotheprevalenceoftheseinfections.ThisstudyaimedtodeterminetheriskfactorsforCRKPbloodstreaminfectionsinahospitalinChina.

Thestudyfoundthattwoparticularriskfactors,indwellingcathetersandmechanicalventilation,wereindependentfactorsthatcontributedtobloodstreaminfections.Thesefindingsemphasizetheimportanceofreducingtheuseofindwellingcathetersandimprovingthemanagementofmechanicalventilationinhospitalsettings.Inaddition,targetedmeasuresshouldbetakentoreducebloodstreaminfections,suchasimprovinginfectioncontrolpracticesandincreasingawarenessamonghealthcareworkers.

TheresultsofthisstudyhighlighttheneedforongoingmonitoringofinfectionratesandtheimplementationoftargetedinterventionstoreducetheprevalenceofCRKPbloodstreaminfections.Byidentifyingandaddressingriskfactors,healthcareproviderscanmitigatetheadverseeffectsoftheseinfectionsonpatientoutcomesandreducetheburdenofhealthcare-associatedinfections.Itiscrucialtoremainvigilantandimplementevidence-basedpracticestopreventandcontrolthespreadofCRKPInadditiontomonitoringandinterventions,thereareseveralotherstrategiesthatcanbeemployedtoreducetheprevalenceofCRKPbloodstreaminfections.Onesuchstrategyisantimicrobialstewardship,whichinvolvesoptimizingtheuseofantibioticstoreducethedevelopmentandspreadofantibiotic-resistantorganisms.Thiscanbeachievedthroughtheimplementationofantibioticguidelinesandprotocols,aswellasthrougheducationandtrainingofhealthcareproviders.

Anotherstrategyisinfectioncontrol,whichinvolvespreventingthespreadofinfectionswithinhealthcarefacilities.Thiscanbeachievedthroughtheuseofstandardprecautions,suchashandhygiene,personalprotectiveequipment,andenvironmentalcleaning,aswellasthroughtargetedinterventions,suchasscreeningandisolationofpatientswithCRKP.

EducationandawarenesscampaignscanalsoplayanimportantroleinreducingtheprevalenceofCRKPbloodstreaminfections.Byeducatinghealthcareprovidersandpatientsabouttherisksandconsequencesofantibioticresistance,aswellasaboutstrategiesforpreventionandcontrol,awarenesscanberaisedandbehaviorcanbechanged.

Finally,researchintonewtreatmentsforCRKPinfectionsisessentialinordertoprovideeffectiveoptionsforpatientswhododeveloptheseinfections.Thisincludesthedevelopmentofnewantibiotics,aswellasalternativetreatmentmodalities,suchasphagetherapyandimmunotherapy.

Inconclusion,CRKPbloodstreaminfectionsposeasignificantthreattopatientoutcomesandhealthcare-associatedinfections.Ongoingmonitoring,targetedinterventions,andtheimplementationofevidence-basedstrategiesareessentialtoreducingtheprevalenceoftheseinfectionsandmitigatingtheiradverseeffects.Byworkingtogether,healthcareproviders,researchers,andpolicymakerscancontinuetoadvanceeffortstopreventandcontrolthespreadofCRKPandotherantibiotic-resistantorganismsInadditiontothemeasuresdiscussedabove,itiscrucialtoemphasizeeducationandawarenessamonghealthcareworkersandpatientsalikeregardingtheproperuseofantibioticsandhandhygienepractices.Overuseandmisuseofantibioticscanleadtotheemergenceandspreadofantibiotic-resistantorganisms,whichcanbeespeciallychallenginginthecaseofbloodstreaminfections.Robustantimicrobialstewardshipprogramsandinfectionpreventionandcontrolprotocolsneedtobeinplacetocombatthegrowingthreatofantibioticresistanceinhealthcaresettings.

Furthermore,researchintonewantibioticsandalternativeantimicrobialtreatmentsisimperative,asthedevelopmentofnewdrugshasnotkeptpacewiththeemergenceofantibiotic-resistantorganisms.Collaborationsbetweenresearchers,pharmaceuticalcompanies,andgovernmentagenciesarenecessarytoacceleratethediscoveryanddevelopmentofnewantibioticsandotherinnovativetherapies.

Finally,acoordinatedglobalapproachisneededtoaddressthisissue,asantibioticresistanceknowsnogeographicalorpoliticalboundaries.Internationalcollaborations,regulations,andguidelinescanhelptoensurethatantibioticuseisoptimized,infectionpreventionandcontrolmeasuresarereinforced,andthespreadofantibiotic-resistantorganismsiscontrolled.

Inconclusion,bloodstreaminfectionscausedbyantibiotic-resistantorganisms,suchasCRKP,poseasignificantthreattopatientoutcomesandhealthcare-associatedinfections.Targetedinterventions,ongoingmonitoring,andtheimplementationofevidence-basedstrategiesareessentialtoreducingtheprevalenceoftheseinfectionsandmitigatingtheiradverseeffects.Byworkingtogether,healthcareproviders,

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