5-Hydroxymethyl-2-deoxyuridine-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE5-Hydroxymethyl-2'-deoxyuridineCat.No.:HY-129983CASNo.:5116-24-5分?式:C??H??N?O?分?量:258.23作?靶點(diǎn):HSV作?通路:Anti-infection儲(chǔ)存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:≥125mg/mL(484.06mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.8725mL19.3626mL38.7252mL5mM0.7745mL3.8725mL7.7450mL10mM0.3873mL1.9363mL3.8725mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性5-Hydroxymethyl-2'-deoxyuridine核苷類似物。5-Hydroxymethyl-2'-deoxyuridine抑制多種?類??病細(xì)胞系的復(fù)制IC50值為1.7-5.8μM。5-Hydroxymethyl-2'-deoxyuridine延長(zhǎng)了攜帶L1210??病的??的存活時(shí)間。5-Hydroxymethyl-2'-deoxyuridine可?于細(xì)胞復(fù)制和??病的研究。體外研究5-Hydroxymethyl-2'-deoxyuridine(0-10μM)inhibitsthereplicationofSarcoma180cellsandEhrlichascites1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEcarcinomacellswithED50valuesof8.5and4μM,respectively[1].5-Hydroxymethyl-2'-deoxyuridineinhibitsherpessimplexvirustype1(HSV-1)pyrimidine2’-deoxyribonucleosidekinasewithaKivalueof3.5μM[1].5-Hydroxymethyl-2'-deoxyuridineinhibitsthereplicationofmultiplehumanleukemiacelllineswithIC50valuesof1.7-5.8μM[2].5-Hydroxymethyl-2'-deoxyuridine(10-100μM)showsdose-dependenttoxicityagainstahumanacutepromyelocyticleukemiacellline[2].體內(nèi)研究5-Hydroxymethyl-2'-deoxyuridine(0,5and50mg/kg;i.p.;once)increasesthesurvivalofDBA/2micecarryingL1210leukemia[3].REFERENCES[1].ShiauGT,etal.Synthesisandbiologicalactivitiesof5-(hydroxymethyl,azidomethyl,oraminomethyl)-2'-deoxyuridineandrelated5'-substitutedanalogues.JMedChem.1980Feb;23(2):127-33.[2].KahilainenLI,etal.5-Hydroxymethyl-2'-deoxyuridine.CytotoxicityandDNAincorporationstudiedbyusinganovel[2-14C]-derivativewithnormalandleukemichumanhematopoieticcells.ActaChemScandB.1985;39(6):477-84.[3].JAVilpo,etal.5-Hydroxymethyl-2′-Deoxyuridine:StudiesofAntileukemicPropertiesinVitroandinVivo.NucleosidesandNucleotides.1987.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchu