阿爾茨海默癥英語介紹

Alzheimer’sDisease阿爾茨海默癥

阿爾茨海默癥英語介紹RonaldWilsonReagan羅納德·威爾遜·里根第40任（第49-50屆）美國總統(tǒng)president“IknowI'monmywaytothetwilight.Iknowthere'salwaysabrightdawnaheadoftheUnitedstates.Thankyou,myfriends.MayGodblessyouforever.”阿爾茨海默癥英語介紹briefintroduction01Pathogeny＆Treatment03Clinicalmanifestation02Other04Catalog阿爾茨海默癥英語介紹

briefintroduction

1阿爾茨海默癥英語介紹What?Alzheimer'sdisease(AD)isaprogressiveneurodegenerativedisorder.臨床癥狀Clinicalsymptom記憶障礙dysmnesia失語aphasia失認(rèn)agnosia執(zhí)行功能障礙executivedysfunction癡呆dementiaThediseaseusuallybeginsafterage60,andriskgoesupwithage.阿爾茨海默癥英語介紹TwotypesAlzheimer'sdisease(AD)

<65yearsoldseniledementia(SDAT)≥65yearsold阿爾茨海默癥英語介紹NameIn1906,ADisnamedbyDr.AloisAlzheimer,aGermandoctor.Dr.Alzheimernoticedchangesinthebraintissueofawomanwhohaddiedofanunusualmentalillness.Hefoundabnormalclumps.ScientistsalsohavefoundotherbrainchangesinpeoplewithAD.Nervecellsdieinareasofthebrainthatarevitaltomemoryandothermentalabilities.阿爾茨海默癥英語介紹

Clinicalmanifestation

2阿爾茨海默癥英語介紹Clinicalmanifestation

Ⅰ期Ⅱ期Ⅲ期death1-3

years2-10

years8-12yearsMilddementiaModeratedementiaSeveredementiaMorewomenthanmen7:5~4:6Diseaseforupto10-20years阿爾茨海默癥英語介紹

DegradationofmemoryandcognitionWilliamUtermohlen的自畫像阿爾茨海默癥英語介紹Degradationofmemoryandcognition

WilliamUtermohlenisanAmericanartist,in1995hewasdiagnosedwithAlzheimer'sdisease.Sincethen,hehasdecidedtotakeadvantageofthelimitedtimeavailabletoretainmemoryandbetterunderstandhimselfthroughselfportraits.Williaminsistedthe5NewYearpaintingsselfportrait,untilcompletelyforgottenhowtodraw.Fromtheuseofskilleddrawing,darkportrayalofvividfeatures,tothesamecolor,shapedeformation,selfportraitbecamemoreandmoreabstract(picturedabove).阿爾茨海默癥英語介紹Degradationofmemoryandcognition

"theeffectsofAlzheimer'sdiseaseontherightparietallobeofthebrainareparticularlysevere,whichdirectlyaffectstheabilityofthebraintovisualizeanddeveloptheabilitytodrawpicturesofthebrain."saidDr.BruceMiller,aneurologist.Hisworkbecamemoreabstract,maybetheparietalfunctiondamaged,causingblindness.Whatkindofchangeshaveoccurredinthebrainsofpatientswithdementia,whichisnotyetfullyunderstoodbytheworld'sacademia.阿爾茨海默癥英語介紹

Pathogeny＆Treatment

3阿爾茨海默癥英語介紹PathogenesishypothesisofAD阿爾茨海默癥英語介紹PathogenyAbnormalamyloidbetacelldepositioninneuronsAbnormalphosphorylationoftauproteinvs阿爾茨海默癥英語介紹Betaamyloid(bluecurve)andTauprotein(orangecurve)Researchpaperspublishedinrecent30years阿爾茨海默癥英語介紹Treatmentincreasetheconcentrationofacetylcholine(Ach)inthebrainpromotingsurvivalofcholinergicneuronsinthebrainorimprovingtheirnerveconductionfunctionreducingtheproductionorpromotingdegradationofbetaamyloid阿爾茨海默癥英語介紹Other4阿爾茨海默癥英語介紹StillAliceFilmThefilmtellsthestoryofAliceHowlandinseriouslyADb