臨床藥物評(píng)價(jià)

鐘寶琳，黃桂明，李以平，陳以建，李優(yōu)春Clinicalanalysisofdexmedetomidineinintraoperativewake-uptestduringlanguagefunctionalsurgerywithnarcotrendmonitorZHONGBao-lin,HUANGGui-ming,LIYi-ping,CHENYi-jian,LIYou-chun（DepartmentofAnesthesiology,ThePeople’sHospitalofGanzhou,Ganzhou

排除標(biāo)準(zhǔn)東嘉博制藥有限公司生產(chǎn)；鹽酸瑞芬太尼注射液，規(guī)格:每支1mg，批號(hào)：6140405，宜昌人福藥業(yè)有限責(zé)任公司生產(chǎn)。持續(xù)測(cè)壓。以鹽酸戊乙奎醚0.02㎎㎏-1、咪達(dá)唑侖1㎎、丙泊酚2㎎㎏-1、羅庫(kù)溴銨0.8㎎㎏-1誘導(dǎo)，插入喉罩，通氣滿意后以丙泊酚4μg·mL-1，瑞芬太1min-sxsControlGender41.29土41.17土2T0、T1、T2T3、T4血壓、心率差異無(wú)統(tǒng)計(jì)學(xué)意(>0.05)，試驗(yàn)組T5T6和T7血壓、心率明顯低于對(duì)照組（P<0.05），2組各時(shí)點(diǎn)N值差異無(wú)統(tǒng)計(jì)學(xué)意義（P0.5）。2T5、6和7（>0.0），2組4N2。表2喚醒前及喚醒期間情況對(duì)比（sTable2Comparisonbeforewake-upandduringwake-

xsControlControlControlControlControl5ControlT0:Atthebeginningofanesthesia;T1:Beforecutskin;T2:Whenthecraniotomy;T3:Wakeingup;T4andT5:Atevery5minbefore10minofthebeginningofwakeingup;T6:10minbeforetheendofwakeingup;T7:Theendofwakeingup;Comparedwithcontrolgroup,*P<0.05)RozetI.Anesthesiaforfunctionalneurosurgery:theroleofdexmedetomidine[J].Curr Anaesthesiol,2008,21:537-GaravagliaMM,DasS,CusimanoMD,etal.Anestheticapproachtohigh-riskpatientsandprolongedawakecraniotomyusingdexmedetomidineandscalpblock[J].JNeurosurgAnaesthesiol,2014,26:226-233.范鳳飛.[J].實(shí)用醫(yī)學(xué)雜志2012,28:1174-黎平.[J].臨床麻醉學(xué)雜志2011,27:755-FaragE,ArgaliousM,Abd-elsayedA,etal.Theuseofdexmedetomidineinanesthesiaandintensivecare:areview[J].CurrPharmDes,2012;18:6257-ShenSL,ZhengJY,ZhangJ,etal.Comparisonofdexmedetomidineandpropofolforconscioussedationinawakecraniotomy:aprospective,double-blind,randomized,andcontrolledclinicaltrial[J].AnnPharmacother,2013,47:1391-1399.KreuerS,BiedlerA,LarsenR,etal.Narcotrendmonitoringallowsfasteremergenceandareductionofdrugconsumptioninpropofol-remifentanilanesthesia[J].Anesthesiol,2003,99:34-41.Rin?slH,FleckT,DworschakM.BrainischemiainstantaneouslytrackedbythenarcotrendEEGdevic