鎮(zhèn)痛藥的鎮(zhèn)痛作用

鎮(zhèn)痛藥的鎮(zhèn)痛作用班級姓名實(shí)驗(yàn)要求：觀察鎮(zhèn)痛藥的鎮(zhèn)痛作用并聯(lián)系臨床應(yīng)用。材料：恒溫浴槽、0.4%哌替啶注射液。復(fù)方氨基比林注射液、生理鹽水，小白鼠、1ml注射器、天平。實(shí)驗(yàn)操作：調(diào)節(jié)恒溫浴槽的溫度為55℃±0.5℃本組內(nèi)分工，一人看表發(fā)令，一人拿鼠及觀察，一人保持水溫及記錄結(jié)果。當(dāng)看表人發(fā)令時(shí)，立即將一鼠放入恒溫浴槽的熱板上。以小鼠舔后腳趾為痛覺指標(biāo)，計(jì)算從放入至有痛覺為止所需時(shí)間為痛閾值。用此法反應(yīng)在40秒內(nèi)小白鼠3只。依次測定每只小白鼠正常痛閾值，二次的平均值為給藥前的痛閾值。按下述藥物依次給藥，每鼠每10分鐘測定一次痛閾值，共60分鐘。小白鼠藥物用量用藥方式甲鼠0.4%哌替啶溶液0.1ml/10g腹腔注射乙鼠復(fù)方氨基比林0.1ml/10g腹腔注射丙鼠生理鹽水0.1mi/10g腹腔注射將結(jié)果記錄于統(tǒng)計(jì)表上，并以全班各組痛閾值為計(jì)算依據(jù)。按下述公式計(jì)算痛閾值提高的百分率。 痛閾值提高百分率=（用藥后痛閾值-用藥前平均痛閾值）/用藥前平均痛閾值*100%【說明】 如60秒內(nèi)無反應(yīng)，應(yīng)把鼠取出，并按60為計(jì)算依據(jù)?！窘Y(jié)果】實(shí)驗(yàn)數(shù)據(jù)：小組哌替啶復(fù)方氨基比林生理鹽水t-檢驗(yàn):雙樣本異方差假設(shè)117.4614.009.50212.5018.0023.01變量1變量2313.1010.0012.36平均13.96511.85318182412.406.7019.50方差18.18491511.46530136516.508.009.50觀測值1111612.5012.007.00假設(shè)平均差079.5016.007.91df1985.6610.8512.00tStat1.28629012915.0013.526.00P(T<=t)單尾0.1068979441021.0012.0019.50t單尾臨界1.7291327921118.009.3220.18P(T<=t)雙尾0.213795888t雙尾臨界2.0930240510min后小組哌替啶復(fù)方氨基比林生理鹽水t-檢驗(yàn):雙樣本異方差假設(shè)12418.62602152012變量1變量23191764平均32.73727273222915.246.27方差355.4477218196.9088218524196觀測值11116602015.24假設(shè)平均差07256012df18810.826.617tStat1.4965066439391411P(T<=t)單尾0.07592525710603312t單尾臨界1.73406359211602010P(T<=t)雙尾0.151850515t雙尾臨界2.10092203720min后小組哌替啶復(fù)方氨基比林生理鹽水t-檢驗(yàn):雙樣本異方差假設(shè)134.822014.72260328變量1變量23232213.7平均37.1918181822.7436363643320.0520方差336.6311764190.8344455560608觀測值111166015.029.25假設(shè)平均差072496df19823.292212.83tStat2.08647152191110.4938P(T<=t)單尾0.025325917105618.6210t單尾臨界1.72913279211242160P(T<=t)雙尾0.050651834t雙尾臨界2.0930240530min后小組哌替啶復(fù)方氨基比林生理鹽水t-檢驗(yàn):雙樣本異方差假設(shè)12113.4110.442361860變量1變量231614.614平均32.1290909123.00727273421.791319方差162.5283691218.23544185281860觀測值1111654.2514.6254.25假設(shè)平均差07464010df2082129.4550.72tStat1.550421998938.91725P(T<=t)單尾0.0683602611046607t單尾臨界1.7247182181124.481560P(T<=t)雙尾0.136720521t雙尾臨界2.08596344140min后小組哌替啶復(fù)方氨基比林生理鹽水t-檢驗(yàn):雙樣本異方差假設(shè)1161360219327變量1變量23181912平均30.4081818219.0163636446016.4513.5方差253.840776485.507405455303710觀測值1111615.7813.567.82假設(shè)平均差07332427df168601019tStat2.051004551926.610.222.5P(T<=t)單尾0.02850714510332427t單尾臨界1.7458836691123.119.9713.7P(T<=t)雙尾0.05701429t雙尾臨界2.11990528550min后小組哌替啶復(fù)方氨基比林生理鹽水t-檢驗(yàn):雙樣本異方差假設(shè)115.1710.3820.282252814變量1變量2311.617.933.4平均28.4590909124.431818184601120方差302.8368891238.25441645252814觀測值1111637.2813.4710.69假設(shè)平均差0717206df208606021.28tStat0.5742117919121510P(T<=t)單尾0.28611339510304510t單尾臨界1.72471821811202060P(T<=t)雙尾0.572226791t雙尾臨界2.085963441數(shù)據(jù)分析：哌替啶痛閾值提高百分率復(fù)方氨基比林痛閾值提高百分率生理鹽水痛閾值提高百分率0分鐘00010分鐘131.74