Mycophenolic-acid-Standard-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEMycophenolicacid(Standard)Cat.No.:HY-B0421RCASNo.:24280-93-1分子式:C??H??O?分子量:320.34作用靶點:Denguevirus;Apoptosis;Bacterial;Fungal;EndogenousMetabolite;Antibiotic;Flavivirus作用通路:Anti-infection;Apoptosis;MetabolicEnzyme/Protease儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Mycophenolicacid(Standard)是Mycophenolicacid的分析標準品。本產品用于研究及分析應用。Mycophenolicacid是一種有效的非競爭性肌苷單磷酸脫氫酶(IMPDH)抑制劑，EC50為0.24μM。Mycophenolicacid對多種RNA病毒具有抗病毒作用，包括流感(influenza)。Mycophenolicacid是一種免疫抑制劑。具有抗血管生成和抗腫瘤作用[1][2]。IC50&TargetMycophenolicacid(MPA)isanimmunosuppressantdrugusedtopreventrejectioninorgantransplantation.ItinhibitsanenzymeneededforthegrowthofTcellsandBcells.Mycophenolicacid(MPA)didnotblocktheinitialphaseofviraltranslationbutdidinterferewithviralproteinsynthesisintheamplificationphase.QuantitativeRT-PCRdemonstratedthatMPApreventedtheaccumulationofviralpositive-andnegative-strandRNAastheinfectionproceeded.Mycophenolicacid(MPA)inhibitsflavivirusinfectionbypreventingsynthesisandaccumulationofviralRNA[1].TheeffectsofMycophenolicacid(MPA)onDENreplicationinmonkeykidney(LLC-MK2)cellswereexamined.MPA(IC50=0.4+/-0.3microM)inhibitedDEN2replication.Quantitativereal-timeRT-PCRofviralRNAandplaqueassaysofvirionsfromDEN2-infectedandMycophenolicacid(MPA)(10microM)-treatedcellsshowedafivefoldincreaseindefectiveviralRNAproductionbycellstreatedwitheachdrug.suggestingthatonemodeofantiviralactionofMPAisbyinhibitionofinosinemonophosphatedehydrogenaseandtherebydepletionoftheintracellularGTPpool[2].REFERENCESStephenRWelch,etal.ScreeningandIdentificationofLujoVirusInhibitorsUsingaRecombinantReporterVirusPlatform.Viruses.2021Jun28;13(7):1255.SophieDomhan,etal.Molecularmechanismsoftheantiangiogenicandantitumoreffectsofmycophenolicacid.MolCancerTher.20081/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemEJun;7(6):1656-68.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseo