Framycetin-sulfate-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEFramycetin(sulfate)(Standard)Cat.No.:HY-17624ARCASNo.:4146-30-9分子式:C??H??N?O??S?分子量:908.88作用靶點:Antibiotic;Bacterial作用通路:Anti-infection儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Framycetin(sulfate)(Standard)是Framycetin(sulfate)的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Framycetinsulfate(NeomycinBsulfate)是一種氨基糖苷類抗生素，是一種有效的RNaseP裂解活性抑制劑，Ki為35μM。Framycetinsulfate競爭RNasePRNA中特定的二價金屬離子結(jié)合位點。Framycetinsulfate抑制IC50&TargetKi:35μM(RNasePcleavageactivity)and13.5μM(hammerheadribozyme)[1]REFERENCESNEMikkelsen,etal.InhibitionofRNasePRNACleavagebyAminoglycosides.ProcNatlAcadSciUSA.1999May25;96(11):6155-60.Childs-DisneyJL,etal.SmallMoleculeTargetingofaMicroRNAAssociatedwithHepatocellularCarcinoma.ACSChemBiol.2016Feb19;11(2):375-80.StampflS,etal.MonovalentiondependenceofneomycinBbindingtoanRNAaptamercharacterizedbyspectroscopicmethods.Chembiochem.2007Jul9;8(10):1137-45.HochI,etal.AntibioticinhibitionofRNAcatalysis:neomycinBbindstothecatalyticcoreofthetdgroupIintrondisplacingessentialmetalions.JMolBiol.1998Sep25;282(3):557-69.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021-