Metoclopramide-hydrochloride-hydrate-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEMetoclopramide(hydrochloridehydrate)(Standard)Cat.No.:HY-17382ARCASNo.:54143-57-6分子式:C??H??Cl?N?O?分子量:354.27作用靶點(diǎn):5-HTReceptor;DopamineReceptor作用通路:GPCR/GProtein;NeuronalSignaling儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Metoclopramide(hydrochloridehydrate)(Standard)是Metoclopramide(hydrochloridehydrate)的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Metoclopramidehydrochloridehydrate是一種有效的5-HT3和多巴胺D2受體拮抗劑，IC50值分別為308nM和483nM。MetoclopramiREFERENCESHirokawaY,et,al.Synthesisandstructure-activityrelationshipsof4-amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamidederivatives,novelandpotentserotonin5-HT3anddopamineD2receptorsdualantagonist.ChemPharmBull(Tokyo).2002Jul;50(7):941-59.RaoAS,et,al.Reviewarticle:metoclopramideandtardivedyskinesia.AlimentPharmacolTher.2010Jan;31(1):11-9.EdwardsCR,et,al.Invivoandinvitrostudiesontheeffectofmetoclopramideonaldosteronesecretion.ClinEndocrinol(Oxf).1980Jul;13(1):45-50.BhosaleKB,et,al.Dose-dependentresponseofcentraldopaminergicsystemstometoclopramideinmice.IndianJExpBiol.1997Jun;35(6):618-22.GomesRCT,et,al.Effectsofmetoclopramideonthemouseanteriorpituitaryduringtheestrouscycle.Clinics(SaoPaulo).2011;66(6):1101-4.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792F