Peimine-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEPeimine(Standard)Cat.No.:HY-N0212RCASNo.:23496-41-5分子式:C??H??NO?分子量:431.65作用靶點(diǎn):Apoptosis;Apoptosis;InterleukinRelated;InterleukinRelated;TNFReceptor;TNFReceptor;p38MAPK;p38MAPK;NF-κB;NF-κB作用通路:Apoptosis;Immunology/Inflammation;MAPK/ERKPathway;NF-κB儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Peimine(Standard)是Peimine的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Peimine(Verticine;Dihydroisoimperialine)是一種具有口服活性的天然產(chǎn)物。Peimine具有消炎、鎮(zhèn)痛、止咳的作用。Peimine可用于癌癥和炎癥相關(guān)研究[1][2][3][4][5][6][7]。REFERENCESYiPF,etal.Peimineimpairspro-inflammatorycytokinesecretionthroughtheinhibitionoftheactivationofNF-κBandMAPKinLPS-inducedRAW264.7macrophages.ImmunopharmacolImmunotoxicol.2013Oct;35(5):567-72.ChenK,LvZT,ZhouCH,etal.Peiminesuppressesinterleukin?1β?inducedinflammationviaMAPKdownregulationinchondrocytes.IntJMolMed.2019;43(5):2241-2251.TanH,etal.PeimineinhibitsthegrowthandmotilityofprostatecancercellsandinducesapoptosisbydisruptionofintracellularcalciumhomeostasisthroughCa2+/CaMKII/JNKpathway.JCellBiochem.2020Jan;121(1):81-92.LiuC,etal.Synergisticanti-inflammatoryeffectsofpeimine,peiminine,andforsythosideacombinationonLPS-inducedacutelunginjurybyinhibitionoftheIL-17-NF-κB/MAPKpathwayactivation.JEthnopharmacol.2022Sep15;295:115343.ChenLH,etal.Sexdependentpharmacokinetics,tissuedistributionandexcretionofpeimineandpeiminineinratsassessedbyliquidchromatography-tandemmassspectrometry.JEthnopharmacol.2013Jan9;145(1):77-84.YiPF,etal.Peimineimpairspro-inflammatorycytokinesecretionthroughtheinhibitionoftheactivationofNF-κBandMAPKinLPS-inducedRAW264.7macrophages.ImmunopharmacolImmunotoxicol.2013Oct;35(5):567-72.XuJ,etal.Peimine,amainactiveingredientofFritillaria,exhibitsanti-inflammatoryandpainsuppressionpropertiesatthecellularlevel.Fitoterapia.2016Jun;111:1-6.YiPF,etal.Peimineimpairspro-inflammatorycytokinesecretionthroughtheinhibitionoftheactivationofNF-κBandMAPKinLPS-1/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemEinducedRAW264.7macrophages.ImmunopharmacolImmunotoxicol.2013Oct;35(5):567-72.ChenK,LvZT,ZhouCH,etal.Peiminesuppressesinterleukin?1β?inducedinflammationviaMAPKdownregulationinchondrocytes.IntJMolMed.2019;43(5):2241-2251.TanH,etal.PeimineinhibitsthegrowthandmotilityofprostatecancercellsandinducesapoptosisbydisruptionofintracellularcalciumhomeostasisthroughCa2+/CaMKII/JNKpathway.JCellBiochem.2020Jan;121(1):81-92.LiuC,etal.Synergisticanti-inflammatoryeffectsofpeimine,peiminine,andforsythosideacombinationonLPS-inducedacutelunginjurybyinhibitionoftheIL-17-NF-κB/MAPKpathwayactivation.JEthnopharmacol.2022Sep15;295:115343.ChenLH,etal.Sexdependentpharmacokinetics,tissuedistributionandexcretionofpeimineandpeiminineinratsassessedbyliquidchromatography-tandemmassspectrometry.JEthnopharmacol.2013Jan9;145(1):77-84.YiPF,etal.Peimineimpairspro-inflammatorycytokinesecretionthroughtheinhibitionoftheactivationofNF-κBandMAPKinLPS-inducedRAW264.7macrophages.ImmunopharmacolImmunotoxicol.2013Oct;35(5):567-72.XuJ,etal.Peimine,amainactiveingredientofFritillaria,exhibitsanti-inflammatoryandpainsuppressionpropertiesatthecellularlevel.Fitoterapia.2016Jun;111:1-6.McePdfHeightCaution:Productha