乙腦參賽英語幻燈2010914

1、Japanese encephalitisCapital Medical University, Beijing You an HospitalZhou Li, M.DWhats wrong with them?Whats wrong with them? Introduction Japanese encephalitis is an acute infectious disease of central nervous system, caused by mosquito-borne Japanese encephalitis virus. Its presentations includ

2、e high fever, confusion or coma, convulsion, pathological reflex and meningeal irritation. Fatality is about 25-30%. 10% result in permanent neuropsychiatric sequelae. Epidemiology Sources of infection Route of transmission Susceptible population Epidemiological featureSources of infectionHuman bein

3、gs and animals are both sources of infectionzoonosisHumans are not the main source of infection（viremia5 days）Pigs are the primary amplifying hosthigh infective rate, long time viremia, large feeding areaOther domestic animalsand water birds can also be amplifying hostRoute of transmission: Bite of

4、infected mosquitoesmost important vectorCulex mosquitoesNatural cycle of JEVSusceptible populationzoonosisSusceptible populationHumans are generally susceptible, most infections are asymptomatic which confer life-long immunityIn endemic areas, children have the highest attack rates (high risk age：2-

5、6 years old)In endemic areas, attack rates of adults (including the aged) are increasing in recent yearsEpidemiological featureMost prevalent in Southeast Asia and Western pacific rigionMost cases in temperate and subtropical areas occur from June to September, while in tropical areas occur througho

6、ut the yearGlobally, more than 45,000 cases and more than 10,000 deaths are reported each yearProphylaxisSource of infectionSusceptible populationtransmissionControl the sourceBlock transmissionEnhance immunityVaccinationMosquitoes controlSwine managementSummary (1) Where?-most prevalent in Southeast Asia and the Far East Who?-children have the highest attack rates (in endemic areas) When?-most cases in temperate and subtropical areas occur from June to SeptemberSummary (2) Primary amplifying host-pigs M