CMV-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/CMV.html CMVCytomegalovirusCytomegalovirus (CMV) is a double-stranded DNA virus and is a member of the ubiquitous family of herpesviruses.Cytomegaloviruses escape immunological clearance and persist throughout life in the infected host. Yet, the stability of th

2、e balanceof this virus-host interaction is dependent upon the state of the cellular immune response, and usually requires the function ofspecific CD8 T lymphocytes.Human cytomegalovirus is a member of the viral family known as herpesviruses, Herpesviridae, or human herpesvirus-5 (HHV-5).Human cytome

3、galovirus infections commonly are associated with the salivary glands. CMV infection may be asymptomatic inhealthy people, but it can be life-threatening in an immunocompromised patient. Congenital cytomegalovirus infection can causemorbidity and even death. After infection, CMV often remains latent

4、, but it can reactivate at any time. Eventually, it causesmucoepidermoid carcinoma, and it may be responsible for prostate cancer.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/CMV.html CMV HYPERLINK https:/www.MedChemE/Targets/CMV.html HYPERLINK https:/www.MedChemE/Targets/CMV.html Inhibitors

5、 HYPERLINK https:/www.MedChemE/Ancitabine-hydrochloride.html Ancitabine HYPERLINK https:/www.MedChemE/Ancitabine-hydrochloride.html HYPERLINK https:/www.MedChemE/Ancitabine-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/Ancitabine-hydrochloride.html (Cyclocytidine hydrochloride;Cyclo

6、-CMP hydrochloride; Cyclo-C) Cat. No.: HY-N0093 HYPERLINK https:/www.MedChemE/Artemisone.html Artemisone(Artemifone; BAY 44-9585) Cat. No.: HY-19502Ancitabine (hydrochloride) is an importantantileukemia drugs.Artemisone (Artemifone) is a potent andsemi-synthetic antimalarial, inhibits P.falciparum s

7、trains, with a mean IC of 0.8350nM. Artemisone is also a potent inhibitor ofhuman CMV.Purity: 98.97%Clinical Data: LaunchedSize: 10 mM 1 mL, 200 mg, 1 gPurity: 98.0%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/B220.html B220Cat. No.: HY-100272 HYPE

8、RLINK https:/www.MedChemE/bisindolylmaleimide-iv.html Bisindolylmaleimide HYPERLINK https:/www.MedChemE/bisindolylmaleimide-iv.html HYPERLINK https:/www.MedChemE/bisindolylmaleimide-iv.html IV(Arcyriarubin A) Cat. No.: HY-108254B220 is an antiviral agent which can inhibit thegrowth of HSV-1, HSV-2 a

9、nd humancytomegalovirus (CMV).Bisindolylmaleimide IV (Arcyriarubin A) is apotent protein kinase C (PKC) inhibitor, withIC s ranging from 0.1 to 0.55 M.50Bisindolylmaleimide IV also inhibits PKA(IC =3.1-11.8M).50Purity: 99.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mgPurity: 98%Clini

10、cal Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/braco-19.html Braco-19 HYPERLINK https:/www.MedChemE/braco-19.html HYPERLINK https:/www.MedChemE/braco-19-trihydrochloride.html Braco-19 HYPERLINK https:/www.MedChemE/braco-19-trihydrochloride.html HYPERLINK http

11、s:/www.MedChemE/braco-19-trihydrochloride.html trihydrochlorideCat. No.: HY-15523 Cat. No.: HY-15523ABraco-19 is apotent telomerase/telomere inhibitor,preventing the capping and catalytic action oftelomerase.Braco-19 trihydrochloride is apotent telomerase/telomere inhibitor,preventing the capping an

12、d catalytic action oftelomerase.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.98%Clinical Data: No Development ReportedSize: 1 mg HYPERLINK https:/www.MedChemE/CMX001.html Brincidofovir HYPERLINK https:/www.MedChemE/CMX001.html HYPERLINK https:/www.MedChemE/Brivudine.ht

13、ml Brivudine(CMX001; HDP-CDV) Cat. No.: HY-14532 (Bromovinyldeoxyuridine; BVDU) Cat. No.: HY-13578Brincidofovir (CMX001), the lipid-conjugatedprodrug of Cidofovir (HY-17438), is an orallyavailable, long-acting antiviral.Brivudine is a thymidine analogue with antiviralactivity, indicated for the earl

14、y treatment ofacute herpes zoster.Purity: 99.06%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 2 mg, 5 mg, 10 mg, 25 mg, 50 mgPurity: 98%Clinical Data: LaunchedSize: 10 mM 1 mL, 25 mg, 50 mg, 100 mg, 200 mg HYPERLINK https:/www.MedChemE/calcium-trinatrium-diethylenetriaminepentaacetic-acid-

15、hydrate.html Calcium HYPERLINK https:/www.MedChemE/calcium-trinatrium-diethylenetriaminepentaacetic-acid-hydrate.html HYPERLINK https:/www.MedChemE/calcium-trinatrium-diethylenetriaminepentaacetic-acid-hydrate.html trinatrium HYPERLINK https:/www.MedChemE/calcium-trinatrium-diethylenetriaminepentaac

16、etic-acid-hydrate.html HYPERLINK https:/www.MedChemE/calcium-trinatrium-diethylenetriaminepentaacetic-acid-hydrate.html diethylenetriaminepentaacetic HYPERLINK https:/www.MedChemE/calcium-trinatrium-diethylenetriaminepentaacetic-acid-hydrate.html HYPERLINK https:/www.MedChemE/calcium-trinatrium-diet

17、hylenetriaminepentaacetic-acid-hydrate.html acid HYPERLINK https:/www.MedChemE/calcium-trinatrium-diethylenetriaminepentaacetic-acid-hydrate.html HYPERLINK https:/www.MedChemE/calcium-trinatrium-diethylenetriaminepentaacetic-acid-hydrate.html hydrate HYPERLINK https:/www.MedChemE/calcium-trinatrium-

18、diethylenetriaminepentaacetic-acid-hydrate.html HYPERLINK https:/www.MedChemE/cef20.html CEF20(Ca-DTPA trisodium salt hydrate) Cat. No.: HY-128370Cat. No.: HY-P1780Calcium trinatrium diethylenetriaminepentaaceticacid hydrate (Ca-DTPA trisodium salt hydrate) is ametal chelator and a useful antidote (

19、such asacute cadmium intoxication).CEF20 is an HLA-A*0201-restricted epitope fromcytomegalovirus pp65 (495-503).Purity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK http

20、s:/www.MedChemE/Cidofovir.html Cidofovir(GS 0504; HPMPC; (S)-HPMPC) Cat. No.: HY-17438 HYPERLINK https:/www.MedChemE/cidofovir-dihydrate.html Cidofovir HYPERLINK https:/www.MedChemE/cidofovir-dihydrate.html HYPERLINK https:/www.MedChemE/cidofovir-dihydrate.html dihydrate(HPMPC dihydrate; (S)-HPMPC d

21、ihydrate) Cat. No.: HY-17438ACidofovir is an anti-CMV drug which can suppressCMV replication by selective inhibition of viralDNA polymerase and therefore prevention of viralreplication and transcription.Cidofovir dehydrate is an injectable antiviralmedication for the treatment of cytomegalovirus(CMV

22、) retinitis, which suppresses virusreplication by selective inhibition of viral DNAsynthesis.Purity: 99.15%Clinical Data: LaunchedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/cyclopropavir.html Cyclopropavir(Filociclovir; ZSM-

23、I-62; MBX-400) Cat. No.: HY-16721 HYPERLINK https:/www.MedChemE/enocitabine.html EnocitabineCat. No.: HY-123523Cyclopropavir (Filociclovir; ZSM-I-62; MBX-400) isa broad-spectrum anti-herpesvirus compound, hasgood antiviral activity against cytomegalovirus(CMV), herpes simplex virus (HHV)-6 and HHV-8

24、 withEC s of 0.7 M to 8 M.50Enocitabine is a nucleoside analog, and is apotent DNA replication inhibitor, and a DNA chainterminator. Enocitabine inhibits the replicationof human cytomegalovirus. Enocitabine hasantileukemic and antiviral activities.Purity: 98.0%Clinical Data: Phase 1Size: 5 mg, 10 mg

25、, 25 mg, 50 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 5 mg, 10 mg HYPERLINK https:/www.MedChemE/fit-039.html FIT-039Cat. No.: HY-18944 HYPERLINK https:/www.MedChemE/floxuridine.html Floxuridine(5-Fluorouracil 2-deoxyriboside) Cat. No.: HY-B0097FIT-039 is a selective, ATP-competitive

26、 and orallyactive CDK9 inhibitor with an IC of 5.8 M for50CKD9/cyclin T1. FIT-039 does not inhibit otherCDKs and other kinases. FIT-039 inhibitsreplication of HSV-1 (IC of 0.69 M), ,human adenovirus, and human CMV.50 HSV-2Floxuridine (5-Fluorouracil 2-deoxyriboside) isa pyrimidine analog and known a

27、san oncology antimetabolite.Purity: 98.02%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mgPurity: 99.76%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg, 200 mg, 500 mg HYPERLINK https:/www.MedChemE/fomivirsen-sodium.html Fomivirsen HYPERLINK https:/www.MedChemE/fomivirsen-sodium.html HYP

28、ERLINK https:/www.MedChemE/fomivirsen-sodium.html sodium HYPERLINK https:/www.MedChemE/fomivirsen-sodium.html HYPERLINK https:/www.MedChemE/ganciclovir.html GanciclovirCat. No.: HY-109528(BW 759; 2-Nor-2-deoxyguanosine) Cat. No.: HY-13637Fomivirsen sodium is an antisense 21 merphosphorothioate oligo

29、nucleotide. Fomivirsen is anantiviral agent that is used cytomegalovirusretinitis (CMV) research, incluiding in AIDs.Ganciclovir (BW 759), a nucleoside analogue, is anorally active antiviral agent with activityagainst CMV. Ganciclovir also has activity invitro against members of the herpes group and

30、some other DNA viruses.Purity: 99.0%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 99.77%Clinical Data: LaunchedSize: 100 mg, 1 g, 5 g HYPERLINK https:/www.MedChemE/ganciclovir-sodium.html Ganciclovir HYPERLINK https:/www.MedChemE/ganciclovir-sodium.html HYPERLINK https:/www.Me

31、dChemE/ganciclovir-sodium.html sodium HYPERLINK https:/www.MedChemE/ganciclovir-sodium.html HYPERLINK https:/www.MedChemE/ganciclovir-d5.html Ganciclovir-d5(BW 759 sodium; 2-Nor-2-deoxyguanosine sodium) Cat. No.: HY-13637A (BW 759-d5; 2-Nor-2-deoxyguanosine-d5) Cat. No.: HY-13637SGanciclovir (BW 759

32、) sodium, a nucleoside analogueand an orally active antiviral agent, showsactivity against CMV. Ganciclovir sodium alsohas activity in vitro against members of theherpes group and some other DNA viruses.Ganciclovir-d5 (BW 759-d5) is the deuteriumlabeled Ganciclovir. Ganciclovir (BW 759), anucleoside

33、 analogue, is an orally active antiviralagent with activity against CMV.Purity: 99.85%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg, 1 gPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/letermovir.html Letermovir(AIC246) Cat. No.: HY-1523

34、3 HYPERLINK https:/www.MedChemE/Maribavir.html Maribavir(1263W94; BW1263W94; GW257406X) Cat. No.: HY-16305Letermovir (AIC246) is a potent inhibitor ofCMV, which targets the viral terminase complexand remains active against virus resistant to DNApolymerase inhibitors.Maribavir is a potent inhibitor o

35、f histonephosphorylation catalyzed by wild-type pUL97 invitro, with an IC of 3 nM. Maribavir has potent50antiviral activity against HCMV andEpstein-Barr virus (EBV).Purity: 99.38%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 99.66%Clinical Data: LaunchedSize: 10 mM 1 mL,

36、 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/ML324.html ML324 HYPERLINK https:/www.MedChemE/ML324.html HYPERLINK https:/www.MedChemE/pmedap.html PMEDAPCat. No.: HY-12725 Cat. No.: HY-106382ML324 is a potent JMJD2 demethylase inhibitorwith antiviral activity. ML324 also exhibitsinhibitio

37、n for the histone demethylase KDM4B,with an IC of 4.9 M.50PMEDAP is a potent inhibitor of humanimmunodeficiency virus (HIV) replication. PMEDAPhas anti-murine cytomegalovirus (MCMV) activity.PMEDAP is a very potent inhibitor of Moloneymurine sarcoma virus (MSV)-induced tumor formationand associated

38、mortality.Purity: 98.60%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/sirt1-in-1.html SIRT1-IN-1 HYPERLINK https:/www.MedChemE/sirt1-in-1.html HYPERL

39、INK https:/www.MedChemE/soyasaponin-ii.html Soyasaponin HYPERLINK https:/www.MedChemE/soyasaponin-ii.html HYPERLINK https:/www.MedChemE/soyasaponin-ii.html IICat. No.: HY-136199 Cat. No.: HY-122920SIRT1-IN-1 is a selective SIRT1 inhibitor with anIC of 0.205 M. SIRT1-IN-1 inhibits SIRT2 with50an IC o

40、f 11.5 M. SIRT1-IN-1, a indole, is a50cytomegalovirus (CMV) inhibitors and hasantiviral activity.Soyasaponin II is a saponin with antiviralactivity. Soyasaponin II inhibits the replicationof HSV-1, HCMV, influenza virus, and HIV-1.Soyasaponin II shows potent inhibition on HSV-1replication.Purity: 98

41、.01%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 99.81%Clinical Data: No Development ReportedSize: 1 mg HYPERLINK https:/www.MedChemE/Tomeglovir.html Tomeglovir HYPERLINK https:/www.MedChemE/Tomeglovir.html HYPERLINK https:/www.MedChemE/tricin.html Tricin(BAY 38-4766) Cat. No.: HY-

42、108261Cat. No.: HY-N1127Tomeglovir is a potent anti-CMV agent,inhibiting processing of viral DNA-concatemers,with IC s of 0.34 M and 0.039 M for HCMV and50MCMV.Tricin is a natural flavonoid present in largeamounts in rice bran. Tricin can inhibit humancytomegalovirus (HCMV) replication byinhibiting CDK9.Purity: 99.45%Clinical Data