AWZ1066S _Anti-Wolbachia Drug - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAWZ1066SCat. No.: HY-114415CAS No.: 2239272-16-1分式: CHFNO分量: 404.39作靶點: Parasite作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 125 mg/mL (309.11 mM; Need ultrasonic)Mass

2、 Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.4729 mL 12.3643 mL 24.7286 mL5 mM 0.4946 mL 2.4729 mL 4.9457 mL10 mM 0.2473 mL 1.2364 mL 2.4729 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分

3、 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.14 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.14 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.14 mM); Clear solut

4、ion1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 AWZ1066S種度特異性的抗 Wolbachia 的候選藥物，可于絲病的短期治療，其在細胞中測得的EC50 值為 2.5 nM。REFERENCES1. Hong WD, et al. AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. Proc Natl Acad SciU S A. 2019 Jan 22;116(4):1414-1419.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: