GeA-69 _PARP14 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGeA-69Cat. No.: HY-108708CAS No.: 2143475-98-1分式: CHNO分量: 300.35作靶點: PARP作通路: Cell Cycle/DNA Damage; Epigenetics儲存式: 4C, sealed storage, away from moisture* In solvent : -80C, 6 months; -20C, 1 month (sealedstorage, away from mo

2、isture)溶解性數(shù)據(jù)體外實驗 DMSO : 125 mg/mL (416.18 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.3294 mL 16.6472 mL 33.2945 mL5 mM 0.6659 mL 3.3294 mL 6.6589 mL10 mM 0.3329 mL 1.6647 mL 3.3294 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇

3、適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.93 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (6.93 mM); Clear solutionBIOLO

4、GICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 GeA-69種選擇性的，細胞滲透性的 PARP14 變構(gòu)抑制劑，靶向作于其 macrodomain 2 (MD2)，Kd 值為 2.1 M 1。IC50 & Target PARP142.1 M (Kd)REFERENCES1. Schuller M, et al. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-RibosePolymerase 14. ACS Chem Biol. 2017 Nov 17;12(11):2866-2874.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa