MK-6240-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMK-6240Cat. No.: HY-101186CAS No.: 1841078-87-2分式: CHFN分量: 278.28作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 12.5 mg/mL (44.92 mM; Need ultrasonic)Mass Solvent1 mg

2、 5 mg 10 mg Concentration制備儲備液1 mM 3.5935 mL 17.9675 mL 35.9350 mL5 mM 0.7187 mL 3.5935 mL 7.1870 mL10 mM 0.3594 mL 1.7968 mL 3.5935 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟?，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液

3、中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1.25 mg/mL (4.49 mM); Suspended solution; Need ultrasonicBIOLOGICAL ACTIVITY物活性MK-6240 種針對 神經(jīng)纖維纏結(jié) (NFTs) 的正電發(fā)射斷層顯像 (PET) 蹤劑，對 NFT 的結(jié)合具有較的特1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE異性和選擇性。IC50 & Target Ki: NFT 1.REFEREN

4、CES1. Walji AM, et al. Discovery of 6-(Fluoro-(18)F)-3- (1H-pyrrolo 2,3-cpyridin-1-yl) isoquinolin-5-amine (18)F-MK-6240): A PositronEmission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs). J Med Chem. 2016 May 26;59(10):4778-89.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 02