Cefdinir-FK-482-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECefdinirCat. No.: HY-B0136CAS No.: 91832-40-5Synonyms: FK-482; CI-983分式: CHNOS分量: 395.41作靶點: Bacterial作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 33.33 mg/mL (84.29 m

2、M; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.32 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.32 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5

3、 mg/mL (6.32 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Cefdinir (FK-482)半合成譜抗菌劑。IC50 & Target Antibacterial 1.體外研究 Cefdinir (FK-482) is a third generation oral cephalosporin antibiotic. Cefdinir (Omnicef) is a semi-synthetic,broad-spectrum antibiotic in the third generation of the cephalosporin clas

4、s, which is proved to be effectivefor common bacterial infections of the ear, sinus, throat, and skin. It can be used to treat infections caused byseveral Gram-negative and Gram-positive bacteria. It is available in US as Omnicef by Abbott Laboratoriesand in India as Cednir by Abbott, Kefnir by Glen

5、mark and Cefdiel by Ranbaxy. As of 2008, cefdinir was thehighest-selling cephalosporin antibiotic in the United States, with more than US$585 million in retail sales ofits generic versions alone 1. Cefdinir (FK-482), a new oral 2-amino-5-thiazolyl cephalosporin, inhibited theluminol-amplified chemil

6、uminescence (LACL) response of human neutrophils stimulated by PMA but notopsonized zymosan, in a concentration-dependent but not time-dependent manner. The LACL response toopsonized zymosan in cytochalasin B-treated neutrophils was, however, inhibited by cefdinir. Furthermore,cefdinir inhibited LAC

7、L generation in cell-free systems consisting of H2O2, NaI, and either horseradishperoxidase or a myeloperoxidase-containing neutrophil extract. Orthodianisidine oxidation in these twoacellular systems was inhibited by cefdinir 2.REFERENCES1. Soejima R. Cefdinir. Jpn J Antibiot. 1992 Oct;45(10):1239-

8、52.2. Labro MT, et al. Cefdinir (CI-983), a new oral amino-2-thiazolyl cephalosporin, inhibits human neutrophil myeloperoxidase in theextracellular medium but not the phagolysosome. J Immunol. 1994 Mar 1;152(5):2447-55.McePdfHeightCaution: Product has not been fully validated for medical applications.For