Dirithromycin-LY237216-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDirithromycinCat. No.: HY-B0643CAS No.: 62013-04-1Synonyms: LY237216分式: CHNO分量: 835.07作靶點(diǎn): Bacterial作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) Ethanol : 50 mg/mL (59.88 mM)

2、DMSO : 33.33 mg/mL (39.91 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.1975 mL 5.9875 mL 11.9750 mL5 mM 0.2395 mL 1.1975 mL 2.3950 mL10 mM 0.1198 mL 0.5988 mL 1.1975 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適

3、當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% EtOH 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (2.99 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% EtOH 90% (20% SBE-CD in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.

4、MedChemESolubility: 2.5 mg/mL (2.99 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% EtOH 90% corn oilSolubility: 2.5 mg/mL (2.99 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Dirithromycin(LY 237216)環(huán)內(nèi)酯類糖肽抗素，能與細(xì)菌核糖體70S中的50S亞基相結(jié)合。REFERENCES1. Brogden, R.N. and D.H. Peters, Dirithromycin. A review of its antimicrobi

5、al activity, pharmacokinetic properties and therapeutic efficacy.Drugs, 1994. 48(4): p. 599-616.2. Wintermeyer, S.M., S.M. Abdel-Rahman, and M.C. Nahata, Dirithromycin: a new macrolide. Ann Pharmacother, 1996. 30(10): p. 1141-9.3. Sides, G.D., et al., Pharmacokinetics of dirithromycin. J Antimicrob Chemother, 1993. 31 Suppl C: p. 65-75.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0