GTS-21-dihydrochloride-DMXB-A-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGTS-21 dihydrochlorideCat. No.: HY-14564ACAS No.: 156223-05-1Synonyms: DMXB-A; DMBX-anabaseine分式: CHClNO分量: 381.3作靶點: nAChR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80

2、C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 H2O : 50 mg/mL (131.13 mM; Need ultrasonic)DMSO : 16.5 mg/mL (43.27 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.6226 mL 13.1130 mL 26.2261 mL5 mM 0.5245 mL 2.6226 mL 5.2452 mL10 mM 0.2623 mL 1.3113 mL 2.6226 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選

3、擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.56 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in s

4、aline)Solubility: 2.5 mg/mL (6.56 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.56 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 GTS-21鹽酸鹽種選擇性7煙堿型酰膽堿受體 (7nAChR) 激動劑。REFERENCES1. Yue Y, et al. GTS-21 attenuates lipopolysacc

5、haride-induced inflammatory cytokine production in vitro by modulating the Akt and NF-Bsignaling pathway through the 7 nicotinic acetylcholine receptor. Int Immunopharmacol. 2015 Dec;29(2):504-12.2. Nullens S, et al. EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCEDINFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE. Shock. 2016 Apr;45(4):450-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379