Esmolol-hydrochloride - Adrenergic Receptor 抑制劑 - 生命科學試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEsmolol hydrochlorideCat. No.: HY-B1392CAS No.: 81161-17-3分式: CHClNO分量: 331.83作靶點: Adrenergic Receptor; Autophagy; Mitophagy作通路: GPCR/G Protein; Neuronal Signaling; Autophagy儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 mo

2、nths-20C 1 month溶解性數據體外實驗 DMSO : 100 mg/mL (301.36 mM)H2O : 50 mg/mL (150.68 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.0136 mL 15.0680 mL 30.1359 mL5 mM 0.6027 mL 3.0136 mL 6.0272 mL10 mM 0.3014 mL 1.5068 mL 3.0136 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，

3、并請注意儲備液的保存式和期限。體內實驗請根據您的實驗動物和給藥式選擇適當的溶解案，配制前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您現現配，當天使；澄清的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (8.29 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solub

4、ility: 2.75 mg/mL (8.29 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (8.29 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Esmolol hydrochloride種 腎上腺素受體抑制劑。IC50 & Target Adrenergic receptor體外研究 Esmolol hydrochloride is the hy

5、drochloride salt form of Esmolol, a short and rapid-acting beta adrenergicantagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity.Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces thecontractility

6、and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygendemands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higherdoses, Esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle,thereby leading to smooth muscle relaxation.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: