Bobcat339-hydrochloride - TET 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBobcat339 hydrochlorideCat. No.: HY-111558A分式: CHClNO分量: 334.2作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 130 mg/mL (388.99 mM; Need ultrasonic)Mass Solvent1 mg 5

2、mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.9922 mL 14.9611 mL 29.9222 mL5 mM 0.5984 mL 2.9922 mL 5.9844 mL10 mM 0.2992 mL 1.4961 mL 2.9922 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體

3、積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (6.49 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (6.49 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.17 mg/mL (6.49 mM); Clear solution1/2 Master o

4、f Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Bobcat339 hydrochloride是基于胞嘧啶的 TET 酶 抑制劑，對(duì) TET1 和TET2 的IC50 值分別 33 M和 73 M。它可于表觀遺傳學(xué)領(lǐng)域研究，并且可作為靶向DNA甲基化和基因轉(zhuǎn)錄新療法的起點(diǎn)。IC50 & Target IC50: 33 M (TET1), 73 M (TET1) 1REFERENCES1. Chua GNL, et al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31;10(2):180-185.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax