AZD-0284 - RORγ Inverse Agonist - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAZD-0284Cat. No.: HY-120384CAS No.: 2101291-07-8分式: CHFNOS分量: 524.43作靶點: ROR作通路: Metabolic Enzyme/Protease儲存式: 4C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/m

2、L (190.68 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.9068 mL 9.5342 mL 19.0683 mL5 mM 0.3814 mL 1.9068 mL 3.8137 mL10 mM 0.1907 mL 0.9534 mL 1.9068 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟?，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配

3、，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 0.83 mg/mL (1.58 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 0.83 mg/mL (1.58 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility:

4、0.83 mg/mL (1.58 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 AZD-0284核受體 ROR 的反向激動劑。 在開發(fā)于治療尋常型斑塊狀銀屑病和呼吸道疾病。IC50 & Target ROR 1REFERENCES1. Narjes, F, et al. The discovery of AZD0284, an inverse agonist of the nuclear receptor RORg. American Chemical Society, 2017 DrugDesign and Delivery Symposium 26 October 2017McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa