2022年執(zhí)業(yè)藥師考試【掌中寶】2個(gè)表格搞定“膠囊劑”所有必備考點(diǎn)

1、最新2022年執(zhí)業(yè)藥師考試【掌中寶】2個(gè)表格搞定“膠囊劑”所有必備考點(diǎn) County continuation records has examined and approved the draft, spirit, believe, comprehensive Yearbook of zhuanglang already prepared draft, entered the phase of evaluation. Civil air defense workCounty continuation records has examined and approved the draft, s

2、pirit, believe, comprehensive Yearbook of zhuanglang already prepared draft, entered the phase of evaluation. Civil air defense workCounty continuation records has examined and approved the draft, spirit, believe, comprehensive Yearbook of zhuanglang already prepared draft, entered the phase of eval

3、uation. Civil air defense work掌中寶| 2個(gè)表格搞定“膠囊劑所有必備考點(diǎn)本文摘自中國(guó)醫(yī)藥科技出版社出版的?2022國(guó)家執(zhí)業(yè)藥師考試必備考點(diǎn)速記掌中寶?，主編：吳從敏、張宇。轉(zhuǎn)載請(qǐng)帶上本段話，且注明來(lái)源藥師在線。膠囊劑概述定義原料藥物與適宜輔料充填于空心膠囊或密封于軟質(zhì)囊材中的固體制劑分類根據(jù)囊殼的差異硬膠囊軟膠囊根據(jù)對(duì)藥物溶解度和釋放模式的不同硬膠囊軟膠囊緩釋膠囊控釋膠囊腸溶膠囊特點(diǎn)優(yōu)點(diǎn)掩蓋藥物的不良嗅味，提高藥物穩(wěn)定性起效快、生物利用度高使液態(tài)藥物固體劑型化藥物的緩、控釋和定位釋藥局限易受溫度和濕度的影響生產(chǎn)本錢高特殊人群口服困難易改變囊壁性質(zhì)的藥物不易制成膠囊

4、劑易改變囊壁性質(zhì)的藥物使囊壁溶化的水溶液或稀乙醇溶液藥物使囊壁軟化的風(fēng)化性藥物會(huì)導(dǎo)致囊壁脆裂的強(qiáng)吸濕性的藥物使明膠變性的醛類藥物使囊材軟化或溶解的含有揮發(fā)性、小分子有機(jī)物的液體藥物使囊壁變軟的O/W型乳劑藥物臨床應(yīng)用與考前須知臨床應(yīng)用口服，溫水送服考前須知整粒吞服，勿去除囊殼1025，相對(duì)濕度35%65%條件下保存舉例克拉霉素膠囊注解主藥：克拉霉素稀釋劑：淀粉崩解劑：淀粉和L-HPC黏合劑：淀粉漿助流劑：微粉硅膠潤(rùn)滑劑：硬脂酸鎂硝苯地平膠丸軟膠囊注解主藥：硝苯地平分散介質(zhì)：PEG400保濕劑：甘油膠囊劑的質(zhì)量要求工程要求水分中藥硬膠囊劑水分含量不得過(guò)9.0%硬膠囊內(nèi)容物為液體或半固體者不檢查水分裝量差異平均裝量或標(biāo)示裝量0.30g，裝量差異限度為10%平均裝量或標(biāo)示裝量0.30g，裝量差異限度為7.5%中藥10%崩解度或溶出度硬膠囊的崩解時(shí)限為30分鐘軟膠囊的崩解時(shí)限為1小時(shí)腸溶膠囊鹽酸溶液中2小時(shí)不加擋板，不得有裂縫或崩解現(xiàn)象人工腸液中加擋板，1小時(shí)應(yīng)全部崩解結(jié)腸腸溶膠囊鹽酸溶液中2小時(shí)不加擋板，不得有裂縫或崩解現(xiàn)象pH6.8磷酸鹽緩沖液