YS-49 - Akt Activator - 生命科學試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEYS-49Cat. No.: HY-15477CAS No.: 132836-42-1分式: CHBrNO分量: 386.28作靶點: Others作通路: Others儲存式: 4C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/mL (258.88 mM)* means

2、soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.5888 mL 12.9440 mL 25.8880 mL5 mM 0.5178 mL 2.5888 mL 5.1776 mL10 mM 0.2589 mL 1.2944 mL 2.5888 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內實驗的作液，建議您

3、現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.47 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.47 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility:

4、 2.5 mg/mL (6.47 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 YS-49 能通過誘導HO-1，抑制管緊張素II刺激的管平滑肌細胞（VSMC）增殖。REFERENCES1. Lee YS, Kim CH, Yun-Choi HS,et al. Cardiovascular effect of a naphthylmethyl substituted tetrahydroisoquinoline, YS 49, in rat andrabbit.

5、 Life Sci. 1994;55(21):PL415-20.2. Kang YJ, Koo EB, Lee YS,et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999;128(2):357-64.3. Yun-Choi HS, Pyo MK, Park KM, et

6、 al. Antithrombotic effects of YS-49 and YS-51-1-naphthylmethyl analogs of higenamine . ThrombRes. 2001;104(4):249-55.4. Pyo MK, Yun-Choi HS, Chang KC, et al. Effects of two tetrahydroisoquinolines (YS-49 and YS-51) on experimental disseminatedintravascular coagulation induced by lipopolysaccharide

7、in rats. Arzneimittelforschung. 2004;54(11):705-10.5. Pyo MK, Kim JM, Jin JL,et al. Effects of higenamine and its 1-naphthyl analogs, YS-49 and YS-51, on platelet TXA2 synthesis andaggregation. Thromb Res. 2007;120(1):81-6.6. Sun JJ, Kim HJ, Seo HG, et al. YS49,1-(alpha-naphtylmethyl)-6,7-dihydroxy-

8、1,2,3,4-tetrahydroisoquinoline,regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. LifeSci. 2008;82(11-12):600-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For