PROTAC-RIPK-degrader-6-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEPROTACRIPKdegrader-6Cat.No.:HY-111870CASNo.:2089205-64-9分?式:C??H??N?O??S?分?量:889作?靶點(diǎn):PROTAC;RIPkinase作?通路:PROTAC;Apoptosis儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(112.49mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.1249mL5.6243mL11.2486mL5mM0.2250mL1.1249mL2.2497mL10mM0.1125mL0.5624mL1.1249mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥7.5mg/mL(8.44mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥7.5mg/mL(8.44mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemE?物活性PROTACRIPKdegrader-6(example1)?種PROTAC類的有效RIPK降解劑。IC50&TargetCereblon體外研究PROTACsisusefulforthetargeteddegradationofproteinsandotherpolypeptideswhichontheoneendbindstothecereblonandontheotherendtothetargetprotein(RIP2kinase).BybringingthetargetproteinincloseproximitytotheE3-Ligase,thesecompoundsformaternarycomplexleadingtopolyubiquitinationofthetargetproteininducingitsdegradation[1].REFERENCES[1].JohnDavidHarlin,etal.Compoundsforthemodulationofrip2kinaseactivity.WO2017046036A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58