Ulipristal-CDB-3236-DataSheet-生命科學(xué)試劑-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEUlipristalCat.No.:HY-14959CASNo.:159811-51-5Synonyms:CDB-3236;DeacetylCDB-2914分?式:C??H??NO?分?量:433.58作?靶點(diǎn):ProgesteroneReceptor作?通路:Others儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:≥250mg/mL(576.59mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.3064mL11.5319mL23.0638mL5mM0.4613mL2.3064mL4.6128mL10mM0.2306mL1.1532mL2.3064mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥6.25mg/mL(14.41mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥6.25mg/mL(14.41mM);Clearsolution1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性Ulipristal(CDB3236)?種選擇性的性孕酮受體(progesteronereceptor)調(diào)節(jié)劑。Ulipristal與孕激素受體結(jié)合，從?抑制PR介導(dǎo)的因表達(dá)，并?擾?殖系統(tǒng)中孕激素的活性。體內(nèi)研究Ulipristal(CDB3236)maysuppressthegrowthofuterineleiomyomatosis.Byinhibitingordelayingovulationandeffectingendometrialtissue,ulipristalcanbeusedasanemergencycontraception[1].REFERENCES[1].LIANAPLES,etal.IsUlipristalAcetateaLiverToxicBiomolecule?Toxicityassessmentofulipristalacetate.REV.CHIM.(Bucharest).McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559