3-Deoxyuridine-5-triphosphate-trisodium-3-dUTP-trisodium-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE3'-Deoxyuridine-5'-triphosphatetrisodiumCat.No.:HY-135780ASynonyms:3'-dUTPtrisodium分?式:C?H??N?Na?O??P?分?量:537.11作?靶點:NucleosideAntimetabolite/Analog;DNA/RNASynthesis;EndogenousMetabolite作?通路:CellCycle/DNADamage;MetabolicEnzyme/Protease儲存?式:-20°C,sealedstorage,awayfrommoistureandlight*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoistureandlight)溶解性數(shù)據(jù)體外實驗H2O:20mg/mL(37.24mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.8618mL9.3091mL18.6182mL5mM0.3724mL1.8618mL3.7236mL10mM0.1862mL0.9309mL1.8618mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoistureandlight)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性3'-Deoxyuridine-5'-triphosphatetrisodium(3'-dUTPtrisodium)?種核苷酸類似物，可抑制DNA依賴性RNA聚合酶I和II(RNApolymerasesI和II)，強烈并競爭性地抑制UTP摻?到RNA中，Ki值為2.0μM。體外研究3'-Deoxyuridine-5'-triphosphate(3'-dUTP)issynthesizedstartingfromcordycepiningoodyield.3'-Deoxyuridine-5'-triphosphatestronglyandcompetitivelyinhibitstheincorporationsofUTPintoRNAbytheRNApolymerases.3'-Deoxyuridine-5'-triphosphatewillbeusefulinstudiesatthemolecularlevelonthe1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemErelationshipoftemplateandsubstrateinRNAsynthesiswithchromatin,isolatednucleiorpermeablecells,becauseitdoesnothaveanyeffectonpoly(rA)synthesis[1].REFERENCES[1].MSaneyoshi,etal.InhibitoryEffectsof3'deoxycytidine5'-triphosphateand3'-deoxyuridine5'-triphosphateonDNA-dependentRNAPolymerasesIandIIPurifiedFromDictyosteliumDiscoideumCells.NucleicAcidsRes.1981Jul10;9(13):3129-38.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-