學(xué)習(xí)2.鉑金品質(zhì)卓爾不群

鉑金品質(zhì)、卓爾不群的新一代鉑鉻合金EESPROMUSElementTM

PlusAgenda新一代鉑鉻合金EES—PROMUSElementPlus臨床研究數(shù)據(jù)對(duì)比Agenda新一代鉑鉻合金EES—PROMUSElementPlus臨床研究數(shù)據(jù)對(duì)比增強(qiáng)可視性提高支撐強(qiáng)度

減少支架彈性回縮支架梁尖端更圓鈍支架節(jié)段更短螺旋形雙連接點(diǎn)支架尖端巢式設(shè)計(jì)提高支架的順應(yīng)性獨(dú)特的花紋設(shè)計(jì)Element?球囊材料：Pebax?雙節(jié)段球囊軸桿設(shè)計(jì)較低的球囊外廓獨(dú)創(chuàng)的鉑鉻合金材質(zhì)（PtCr）先進(jìn)的Bi-Segment支架輸送系統(tǒng)安全、高效的依維莫司藥物與氟化共聚物涂層回顧----PROMUSElement?鉑鉻合金EES的優(yōu)勢(shì)依維莫司及氟化共聚物組合的安全性和有效性，已經(jīng)在各種大規(guī)模臨床研究中得到了印證順應(yīng)性徑向強(qiáng)度輸送性

靈活性藥物聚合物涂層可視性1367245*BostonScientificMarketResearchperformedbyathirdparty,Q32011Q:Onascaleof1to7,1beingnotatallimportantand7beingextremelyimportant,howimportantarethefollowingattributesinyourdecisiontouseadrugelutingstent?N=90USICs介入醫(yī)生的臨床反饋

支架系統(tǒng)的各項(xiàng)性能指標(biāo):輸送性始終排名第1位重要性排名徑向強(qiáng)度靈活性輸送性

軸向強(qiáng)度順應(yīng)性彈性回縮可視性2011年*2012年****Source:GTAQ3’12(n=121USICs;155EUICs;50JPICs;50CNICs);Note:a,baresignificantlydifferentat95%confidencelevelPROMUSElementPlus

是目前最先進(jìn)的EESPROMUS

Element?XienceV?

PROMUS?XiencePrime?

=改變支架構(gòu)型和輸送系統(tǒng)改變支架材質(zhì)支架構(gòu)型和輸送系統(tǒng)PROMUS

Element?PlusXienceXpedition?

改進(jìn)輸送系統(tǒng)改進(jìn)輸送系統(tǒng)

鉑鉻合金PlatinumChromium支架設(shè)計(jì)

Element?Architecture輸送系統(tǒng)PROMUSElement?PlusSDS藥物和聚合物涂層Everolimus&FluorinatedCopolymerPROMUSElement?Plus鉑鉻合金EES的優(yōu)勢(shì)

——全新的輸送系統(tǒng)，領(lǐng)先的雙層球囊設(shè)計(jì)理念！全新的雙層球囊設(shè)計(jì)！全新的雙層球囊設(shè)計(jì)

外層堅(jiān)硬，有效控制球囊形變內(nèi)層柔韌，提高靈活性和跟蹤性獨(dú)特的Bi-SegmentTM

雙節(jié)段軸管設(shè)計(jì)

近端軸管加強(qiáng)推送性遠(yuǎn)端軸管提高靈活性PROMUSElement?Plus鉑鉻合金EES全新的輸送系統(tǒng)—最先進(jìn)的雙層球囊設(shè)計(jì)理念PROMUSElementTM

Plus的輸送系統(tǒng)采用的是全新的雙層球囊設(shè)計(jì)和獨(dú)特的Bi-SegmentTM

雙節(jié)段軸管設(shè)計(jì)ProductDFUs.PROMUSElement?StentStrutThickness:2.25-3.50mm=0.0032”.4.00mm=0.0034.”ThePROMUSStentisaprivate-labeledXienceV?EverolimusElutingCoronaryStentSystemmanufacturedbyAbbottanddistributedbyBostonScientificCorporation.Element?

平臺(tái)的支架梁厚度是當(dāng)今DES中最薄的Dataonfile.2.50mmstentsystems;PROMUSElement?PlusStentSystem,XienceV?StentSystem,XiencePrimeStentSystem,EndeavorStentSystem,ResoluteIntegrityStentSystemn=3.ImagesbyBostonScientific.CognexTestMethod(crimped:distal,mid,proximal).1mm0.0417”0.018”平均支架外徑

尖端外徑0.0397”0.018”XienceV?StentSystemPROMUSElement?PlusStentSystem標(biāo)記帶0.0421”0.021”XiencePrime?StentSystem0.0412”0.019”Endeavor?StentSystem1mm1mm1mm

PROMUSElementTM

Plus

通過(guò)外徑最小，更容易通過(guò)復(fù)雜病變。

0.0418”0.020”ResoluteIntegrity?StentSystem1mm0.4572mm0.4572mm0.4826mm0.5334mm0.508mm1.0084mm1.0592mm1.06934mm1.0465mm1.0617mmPROMUSElement?Plus鉑鉻合金EES全新的輸送系統(tǒng)Illustrationsnotindicativeofclinicalperformance.*InaBostonScientificpreclinicalsetting.Dataonfile.全新的雙層球囊+雙節(jié)段球囊軸桿=更好的輸送性、更低的球囊順應(yīng)性臨床經(jīng)驗(yàn)提示：PROMUSElement?Plus支架系統(tǒng)比PROMUSElement?支架系統(tǒng)輸送時(shí)間

減少15%*PROMUSElement?Plus鉑鉻合金EES全新的輸送系統(tǒng)支架輪廓在輸送性臺(tái)架試驗(yàn)的6項(xiàng)指標(biāo)上，

PROMUSElement?Plus

支架系統(tǒng)均優(yōu)于或等同于PROMUSElement?支架系統(tǒng)支架系統(tǒng)總體的輸送性是由多項(xiàng)參數(shù)共同決定的靈活性705030100-10-30-50-70RelativePerformance(%)

ComparedtothePROMUSElement?PlusStentSystemPROMUSElement?支架系統(tǒng)PEPlus(2.5mmx28mm)系統(tǒng)外徑推送性LEP=LesionEntryProfile.DataonFile.TestingCompletedbyBostonScientific.(2.5mmx28mmStentProducts.N=6forProfile,N=3forFlexibilityandPushPROMUSElement?,PROMUSElement?Plus.)DEC2010.Benchtestresultsmaynotnecessarilybeindicativeofclinicalperformance.PROMUSElement?支架系統(tǒng)表現(xiàn)更好PROMUSElement?Plus支架系統(tǒng)表現(xiàn)更好病變導(dǎo)入外徑跟蹤性尖端靈活性可彎曲程度推送性依維莫司藥物洗脫支架(EES)同類產(chǎn)品XiencePRIME從調(diào)整支架平臺(tái)來(lái)改良輸送性

設(shè)計(jì)特點(diǎn)結(jié)果網(wǎng)眼變長(zhǎng)提高支架的柔軟度更高的連接

提高支架的靈活性近端的系統(tǒng)性末節(jié)環(huán)更容易回撤至大腔內(nèi)支架體環(huán)設(shè)計(jì)改變

近端的末節(jié)支架環(huán)設(shè)計(jì)改變

XIENCEPRIMEXIENCEV海波管更大導(dǎo)管腔TestsperformedbyanddataonfileatAbbottVascular.XIENCEPRIMEXIENCEV連接處的核心鋼絲支持XiencePRIME輸送系統(tǒng)的改變著力于提高原有支架系統(tǒng)的操作效率

人造血管模型

3.0mm支架,n=101234567在人造血管模型中前行的距離XiencePRIME依維莫司藥物洗脫支架系統(tǒng)XiencePRIME改良了支架輸送系統(tǒng)09ACCupdateLEP=LesionEntryProfile.

DataonFile.TestingCompletedbyBostonScientific.(2.5mmx28mmStentProducts.N=6forProfile,N=3forFlexibilityandPush,PROMUSElement?Plus,XienceV?,XiencePrime).DEC2010.Benchtestresultsmaynotnecessarilybeindicativeofclinicalperformance.705030100-10-30-50-70RelativePerformance(%)

ComparedtothePROMUSElement?PlusStentSystemXIENCEPRIMETM支架系統(tǒng)XIENCETMV支架系統(tǒng)在輸送性臺(tái)架試驗(yàn)的6項(xiàng)指標(biāo)上，

PROMUSElement?Plus

支架系統(tǒng)5項(xiàng)占優(yōu)支架輪廓支架系統(tǒng)總體的輸送性是由多項(xiàng)參數(shù)共同決定的靈活性PEPlus(2.5mmx28mm)系統(tǒng)外徑推送性競(jìng)爭(zhēng)產(chǎn)品表現(xiàn)更好PROMUSElement?Plus支架系統(tǒng)表現(xiàn)更好病變導(dǎo)入外徑跟蹤性尖端靈活性可彎曲程度推送力LEP=LesionEntryProfile.DataonFile.TestingCompletedbyBostonScientific.(2.5mmx28mmStentProducts.N=6forProfile,N=3forFlexibilityandPushPROMUSElement?Plus,2.5mmx30mmEndeavorResolute,ResoluteIntegrity).DEC2010.Benchtestresultsmaynotnecessarilybeindicativeofclinicalperformance.705030100-10-30-50-70RelativePerformance(%)

ComparedtothePROMUSElement?PlusStentSystemEndeavorResolute?支架系統(tǒng)ResoluteIntegrity?支架系統(tǒng)在輸送性臺(tái)架試驗(yàn)的6項(xiàng)指標(biāo)上，

PROMUSElement?Plus

支架系統(tǒng)5項(xiàng)占優(yōu)支架輪廓支架系統(tǒng)總體的輸送性是由多項(xiàng)參數(shù)共同決定的靈活性PEPlus(2.5mmx28mm)系統(tǒng)外徑推送性病變導(dǎo)入外徑跟蹤性尖端靈活性可彎曲程度推送性競(jìng)爭(zhēng)產(chǎn)品表現(xiàn)更好PROMUSElement?Plus支架系統(tǒng)表現(xiàn)更好全新的雙層球囊設(shè)計(jì)

外層堅(jiān)硬，有效控制球囊形變內(nèi)層柔韌，提高靈活性和跟蹤性獨(dú)特的Bi-SegmentTM

雙節(jié)段軸管設(shè)計(jì)

近端軸管加強(qiáng)推送性遠(yuǎn)端軸管提高靈活性PROMUSElement?Plus鉑鉻合金EES全新的輸送系統(tǒng)—最先進(jìn)的雙層球囊設(shè)計(jì)理念PROMUSElementTM

Plus的輸送系統(tǒng)采用的是全新的雙層球囊設(shè)計(jì)和獨(dú)特的Bi-SegmentTM

雙節(jié)段軸管設(shè)計(jì)Total:1.321mmResoluteIntegrity?StentSystem1.171mmTotal:1.750mmResoluteIntegrityStentSystem1.476mmDataonfile.ImagestakenbyBostonScientific.2.50mmstentsystems;PROMUSElement?StentSystemn=3,XienceV?StentSystemn=3,XiencePrimeStentSystemn=3,EndeavorStentSystemn=3,ResoluteIntegrityStentSystemn=3.Benchtestresultsmaynotnecessarilybeindicativeofclinicalperformance.Total:1.115mmPROMUS

Element?Plus

StentSystem0.532mmTotal:0.929mmPROMUS

Element?Plus

StentSystem0.437mmTotal:1.381mmXienceV?

StentSystem0.548mmTotal:1.182mmXiencePrime?

StentSystem0.585mmTotal:1.097mmEndeavor?StentSystem0.707mm遠(yuǎn)端球囊懸突加壓到11ATM(1’115kPa)Total:1.634mmXienceV?

StentSystem0.653mmTotal:1.252mmXiencePrime

StentSystem0.566mmTotal:1.377mmEndeavorStentSystem0.963mm遠(yuǎn)端球囊懸突加壓到18ATM(1’824kPa)鉑鉻合金EESPROMUSElement

TM

Plus

擁有最小的支架球囊頭端懸突，可以最大程度降低支架邊緣正常血管內(nèi)膜撕裂的幾率。PROMUSElement?Plus鉑鉻合金EES全新的輸送系統(tǒng)NOMINALDonotexceedratedburstpressure.PressureStentI.D.(mm)atm-kPa2.252.502.753.003.504.0012–12132.252.512.753.043.524.0113–13172.302.572.833.123.614.1214–14202.342.632.883.193.684.1915–15172.382.672.943.243.744.2616–16202.422.712.993.303.804.3217–17242.462.753.043.343.854.3718–18272.502.793.083.383.904.42PROMUSElement?StentandPROMUSElement?PlusStentDFURBPPressureStentI.D.(mm)atm-kPa2.252.502.753.003.504.0011-11172.242.502.722.953.513.9612–12132.292.552.783.013.584.0213–13172.342.602.843.063.634.0814–14202.382.652.893.103.684.1315–15172.422.682.933.143.734.1716–16202.452.722.963.173.774.2117–17242.472.752.993.203.814.2518–18272.502.773.033.243.854.3019-19242.522.803.063.283.914.3620-20272.552.833.093.323.974.4321-21302.572.873.1322-22272.602.903.17PROMUSElementTM

支架系統(tǒng)新一代PROMUSElementTM

Plus

支架系統(tǒng)PROMUSElementTM

與PROMUSElementTM

Plus順應(yīng)性比較：PROMUSElement?Plus鉑鉻合金EES全新的輸送系統(tǒng)PE與PEPlus

支架的順應(yīng)性(Compliance)比較atmatmPROMUSElement?Plus擁有47個(gè)產(chǎn)品型號(hào)，是型號(hào)最多的EESPROMUSElementPlus型號(hào)8

mm12

mm16

mm20

mm24

mm28

mm32

mm38

mm2.25mmNewNew2.50mmNew2.75mmNew3.00mmNew3.50mmNew4.00mmNewPROMUSElement?Plus

支架型號(hào)更齊全EES同類產(chǎn)品XienceV和XiencePRIME的產(chǎn)品型號(hào)StentLengthStentDiameter8121518232833382.252.502.753.003.504.0StentLengthStentDiameter8121518232833382.25x2.502.753.003.504.0XiencePRIME

XienceV

36

46

(mm)3.03.53.754.02.754.755.05.254.503.255.505.75標(biāo)準(zhǔn)命名壓:后擴(kuò)張極限:PROMUSElement?2.252.5to2.75PROMUSElement?Plus3.0to3.54.02.252.5to2.753.0to3.54.0DonotdilatethestentbeyondthelimittabulatedabovePROMUSElement?Plus

鉑鉻合金EES

不同直徑支架的擴(kuò)張極限2.25to3.03.5to4.0XienceV&XiencePRIMEPROMUSElement?Plus

鉑鉻合金EES核磁共振成像(MRI)條件：。包裝更小，占用貨架空間更小，更方便貯存和取用NOTTOSCALE非按比例縮小PROMUSElementTM

9.75”X12.00”X0.75”PROMUSElementTM

Plus

9.50”X9.87”X0.69”PROMUSElement?Plus

新包裝Agenda新一代鉑鉻合金EES—PROMUSElementPlus臨床研究數(shù)據(jù)對(duì)比SPIRITPrimeTrial(CoreSizeCohort)**XiencePrime?Stent(n=401)PLATINUMWorkhorseTrial***PROMUSElement?Stent(n=768)*PresentedbyMartinD.Leon,MD;ACC2011.**XiencePrimeIFU,Nov1,2011.***PlatinumTrial:Stone,etal.JACC2011;57::1700.ResoluteisatrademarkofMedtronicVascular,Inc.XiencePrimeisatrademarkofAbbottLaboratoriesgroupofcompanies.DatafromResultsfromdifferentclinicaltrialsarenotdirectlycomparable.Informationprovidedforeducationaluseonly..ThismaterialisnotintendedfortheU.S.orJapan.Pleaseseeglossary.ResoluteU.S.Trial*Resolute?Stent(n=1,402)Incidencerates%Incidencerates%Incidencerates%PLATINUMWorkhorse臨床研究

12個(gè)月事件率與其他研究結(jié)果之比較*Intent-to-treatpopulation.Resultsfromdif