SPOP-IN-6b-dihydrochloride-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESPOP-IN-6bdihydrochlorideCat.No.:HY-122615B分?式:C??H??Cl?N?O?分?量:573.51作?靶點:Others作?通路:Others儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:41.67mg/mL(72.66mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.7436mL8.7182mL17.4365mL5mM0.3487mL1.7436mL3.4873mL10mM0.1744mL0.8718mL1.7436mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(3.63mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性SPOP-IN-6bdihydrochloride?種有效的斑型POZ蛋?(SPOP)抑制劑，IC50為3.58μM。體外研究SPOP-IN-6bdihydrochlorideshowsIC50sof2-10.2μMforA498,Caki-2,Ketr-3,769-P,0S-RC-2,and786-0cells[1].SPOP-IN-6b(0.1-3.0μM;10hours)dihydrochloridecansuppressSPOPactivity,andthenincreasesuppressioncancersubstrateproteinPTENandDUSP7content[1].體內(nèi)研究SPOP-IN-6b(40-80mg/kg;intraperitonealinjection;daily;for25days;nudemice)dihydrochloridecanslowdownthegrowthoftumourbysuppressingSPOP[1].戶使?本產(chǎn)品發(fā)表的科研?獻?MolCell.2020Nov19;80(4):633-647.e7.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].GuangcaiY,etal.Thepyrido-pyrimidinesof2-imines-5-ketonegroup-2,5-dihydros-1-H-two.CN107141287A.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;