干細(xì)胞之臨床應(yīng)用

干細(xì)胞之臨床應(yīng)用干細(xì)胞之臨床應(yīng)用 醫(yī)界應(yīng)用臍帶血于數(shù)類重大疾病的緊急救治，已經(jīng)十年以上。目前，已有許多疾病應(yīng)用干細(xì)胞（stemcells）來治療，而由于臍帶血中的干細(xì)（cordbloodstemcells）是屬較后期、功能限制在一個(gè)系統(tǒng)干細(xì)胞回復(fù)（regress）成更早期、功能更強(qiáng)的干細(xì)胞，此領(lǐng)圍。一、現(xiàn)階段臍血干細(xì)胞可治療疾病1、血色素疾病與血液異常(HemoglobinopathiesandBloodDisorders)巨細(xì)胞球缺乏性血小板減少癥(AmegakaryocyteThrombocytopenia,AMT)再生不良性貧血(AplasticAnemia)先天性血球細(xì)胞缺乏癥(CongenitalCytopenia)鎌形細(xì)胞貧血(Sickle-cellAnemia)地中海性貧血(Thalassemia)Anemia)

Blackfan-Diamond氏貧血(Blackfan-DiamondEvan氏癥候群(EvanSyndrome)Fanconi氏貧血(FanconiAnemia)Kostmann氏癥候群(KostmannSyndrome)2、惡性病類(Malignancies,Cancers)急性淋巴細(xì)胞性血癌(AcuteLymphocyticLeukemia,ALL)急性骨髓性白血癌(AcuteMyelogenousLeukemia,AML)急性非淋巴細(xì)胞性白血癌(AcuteNonlymphocyticLeukemia,ANL)慢性淋巴細(xì)胞性白血癌(ChronicLymphocyticLeukemia,CLL)慢性骨髓細(xì)胞性白血癌(ChronicMyelocyticLeukemia,CML)年輕型骨髓單核細(xì)胞性白血癌(JuvenileMyelomonocyticLeukemia,JML)骨髓發(fā)育不良癥候群(MyelodysplasticSyndrome,MDS)多發(fā)性骨髓瘤(MultipleMyeloma)固體性腫瘤(SolidTumor)腦瘤(BrainTumors)何杰金氏病(Hodgkin'sDisease)非-何杰金氏淋巴瘤(Non-Hodgkin'sLymphoma)Ewing氏肉瘤(EwingSarcoma)生殖細(xì)胞腫瘤(GermCellTumors)神經(jīng)母細(xì)胞瘤(Neuroblastoma)卵巢癌(OvarianCancer)小細(xì)胞性肺癌(Small-CellLungCancer)睪丸癌(TesticularCancer)3、先天性代謝性缺陷(InbornErrorsofMetabolism)(Adrenoleukodystrophy)淀粉樣變性(Amyloidosis)巴爾—淋巴球癥候群(Bare-LymphocyteSyndrome)先天性角化不良(DyskeratosisCongenita)家族性噬紅血球性淋巴組織細(xì)胞增生癥(FamilialErythrophagocyticLymphohististiocytosis)Gaucher氏疾病(GaucherDisease)Gunter氏疾病(GunterDisease)Hunter氏癥候群(HunterSyndrome)Hurler氏癥候群(HurlerSyndrome)遺傳性神經(jīng)元蠟樣脂褐質(zhì)沉著癥(InheritedNeuronalCeroidLipofuscinosis)Krabbe氏疾?。▼雰哼z傳性腦白質(zhì)萎縮）(KrabbeDisease)Langerhan氏細(xì)胞組織細(xì)胞增生癥(Langerhan'sCellHistiocytosis)Lesch-Nyhan氏疾病(Lesch-NyhanDisease)骨硬化?。ü琴|(zhì)石化病缺乏癥(LeukocyteAdhesionDeficiency)4、免疫缺乏病變(Immunodeficiencies)腺嘌呤去氨酵素缺損(AdenosineDeaminaseDeficiency,ADA)慢性肉芽腫疾病(ChronicGranulomatousDisease,CGD)嚴(yán)重性聯(lián)合免疫缺陷疾病(SevereCombinedImmunodeficiencyDiseases,SCIDs)X-性聯(lián)性淋巴組織增生疾病(X-linkedLymphoproliferativeDisease,KLP)Wiskott-Aldrich癥候群5、自體免疫疾病(AutoimmuneDiseases)多發(fā)性硬化癥(MultipleSclerosis)風(fēng)濕性關(guān)節(jié)炎(RheumatoidArthritis)紅斑性狼瘡(SystemicLupuserythematosus)二、未來干細(xì)胞之臨床應(yīng)用：糖尿病(Diabetes)巴金森氏病(Parkinson'sDisease)阿爾罕默氏?。òV呆病）(Alzheimer'sDisease)脊髓傷害(SpinalC