Ciprofloxacin-lactate-Bay-09867-lactate-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECiprofloxacinlactateCat.No.:HY-W040298CASNo.:97867-33-9Synonyms:Bay-09867lactate分?式:C??H??FN?O?分?量:421.42作?靶點(diǎn):Topoisomerase;Apoptosis;Antibiotic;Bacterial;MitochondrialMetabolism;ReactiveOxygenSpecies作?通路:CellCycle/DNADamage;Apoptosis;Anti-infection;MetabolicEnzyme/Protease;Immunology/Inflammation;NF-κB儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Ciprofloxacin(Bay-09867)lactate?種?服有效的拓?fù)洚悩?gòu)酶IV抑制劑。Ciprofloxacinlactate誘導(dǎo)線粒體DNA和核DNA損傷并導(dǎo)致線粒體功能障礙和活性氧產(chǎn)?。Ciprofloxacinlactate具有抗增殖活性并誘導(dǎo)細(xì)胞凋亡(apoptosis)。Ciprofloxacinlactate?種氟喹諾酮類抗?素，具有強(qiáng)?的抗活性。體外研究Ciprofloxacin(Bay-09867)lactate(5-50μg/mL;0-24h;tendoncells)inhibitscellproliferationandcausescellcyclearrestattheG2/Mphase[1].Ciprofloxacin(Bay-09867)lactateshowspotentactivityagainstY.pestisandB.anthraciswithMIC90of0.03μg/mLand0.12μg/mL,respectively[2].CellCycleAnalysis[1]CellLine:TendoncellsConcentration:5,10,20and50μg/mLIncubationTime:24hoursResult:Decreasedthecellularityoftendoncells.ApoptosisAnalysis[1]CellLine:Tendoncells1/3MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEConcentration:50μg/mLIncubationTime:24hoursResult:ArrestedcellcycleattheG2/Mphaseandinhibitedcelldivisionintendoncells.WesternBlotAnalysis[1]CellLine:TendoncellsConcentration:50μg/mLIncubationTime:0,6,12,17and24hoursResult:Down-regulatedtheexpressionofCDK-1andcyclinBproteinandmRNA.Up-regulatedtheexpressionofPLK-1protein.體內(nèi)研究Ciprofloxacin(Bay-09867)lactate(30mg/kg;i.p.;for24hours;BALB/cmice)hasprotectionagainstY.pestisinmurinemodelofpneumonicplague[3].Ciprofloxacin(Bay-09867)lactate(100mg/kg;i.g.;daily,for4weeks;C57BL/6Jmice)acceleratesaorticrootenlargementandincreasestheincidenceofaorticdissectionandrupturebydecreasesLOXlevelandincreasesMMPlevelsandactivityintheaorticwall[4].Ciprofloxacin(Bay-09867)lactate(100mg/kg;i.g.;daily,for4weeks;C57BL/6Jmice)inducesDNAdamageandreleaseofDNAtothecytosol,mitochondrialdysfunction,andactivationofcytosolicDNAsensorsignaling.Ciprofloxacinlactateincreasesapoptosisandnecroptosisintheaorticwall[4].AnimalModel:BALB/cmice[3]Dosage:30mg/kgAdministration:Intraperitonealinjection;for24hoursResult:Reducedthelungbacterialloadinmurinemodelofpneumonicplague.AnimalModel:C57BL/6Jmice[4]Dosage:100mg/kgAdministration:Oralgavage;daily,for4weeksResult:HadaorticdestructionthatwasaccompaniedbydecreasedLOXexpressionandincreasedMMPexpressionandactivity.AnimalModel:C57BL/6Jmice[4]Dosage:100mg/kg2/3MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEAdministration:Oralgavage;daily,for4weeksResult:CausedmitochondrialDNAandnuclearDNAdamage,leadingtomitochondrialdysfunctionandROSproduction.Increasedapoptosisandnecroptosisintheaorticwall.戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?AdvSci(Weinh).2020Jul21;7(17):2001374.?IntJAntimicrobAgents.2018Aug;52(2):269-271.?EBioMedicine.2022Apr;78:103943.?MicrobiolSpectr.2022Apr25:e0251821.?MicrobiolSpectr.2022Jan12;e0099121.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].TsaiWC,et,al.Ciprofloxacin-mediatedcellproliferationinhibitionandG2/Mcellcyclearrestinrattendoncells.ArthritisRheum.2008Jun;58(6):1657-63.[2].SteenbergenJ,et,al.InVitroandInVivoActivityofOmadacyclineagainstTwoBiothreatPathogens,BacillusanthracisandYersiniapestis.AntimicrobAgentsChemother.2017Apr24;61(5):e02434-16.[3].HamblinKA,et,al.InhaledLiposomalCiprofloxacinProtectsagainstaLethalInfectioninaMurineModelofPneumonicPlague.FrontMicrobiol.2017Feb6;8:91.[4].LeMaireSA,et,al.EffectofCiprofloxacinonSusceptibilitytoAorticDissectionandRuptureinMice.JAMASurg.2018Sep1;153(9):e181804.McePdfHe