Mezigdomide-CC-92480-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMezigdomideCat.No.:HY-129395CASNo.:2259648-80-9Synonyms:CC-92480分?式:C??H??FN?O?分?量:567.61作?靶點(diǎn):E1/E2/E3Enzyme;MolecularGlues;Apoptosis作?通路:MetabolicEnzyme/Protease;PROTAC;Apoptosis儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:5mg/mL(8.81mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.7618mL8.8089mL17.6177mL5mM0.3524mL1.7618mL3.5235mL10mM---------請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性Mezigdomide(CC-92480)?種cereblonE3泛素連接酶調(diào)節(jié)藥物(CELMoD)，以分?膠的?式作?。Mezigdomide與cereblon有較強(qiáng)的親和?，具有抗?髓瘤活性。體外研究Mezigdomideisthesecondcereblonmodulator.Mezigdomide-inducedlossofAiolosandIkarosincultures1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEofPBMCsresultedintheactivationofTcellsandincreasedproductionofIL-2andIFN-γ.MezigdomideiseffectiveinCC-5013,CC-4047,andCC-220-resistantcelllines.Itexertssingle-agentinductionofapoptosisandexhibitsremarkablesynergywithNSC34521[1].REFERENCES[1].NookaAK,etal.MechanismofActionandNovelIMiD-BasedCompoundsandCombinationsinMultipleMyeloma.CancerJ.2019Jan/Feb;25(1):19-31.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax