Berotralstat-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBerotralstatCat.No.:HY-109127CASNo.:1809010-50-1分?式:C??H??F?N?O分?量:562.56作?靶點(diǎn):Ser/ThrProtease作?通路:MetabolicEnzyme/Protease儲存?式:4°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:226.67mg/mL(402.93mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.7776mL8.8879mL17.7759mL5mM0.3555mL1.7776mL3.5552mL10mM0.1778mL0.8888mL1.7776mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥8.5mg/mL(15.11mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性Berotralstat(BCX7353)?種低毒性，有效，?特異性，第?代，具有?服活性的plasmakallikrein抑制劑，?于遺傳性?管?腫(hereditaryangioedema，HAE)的研究。Berotralstat通過阻斷plasmakallikrein釋放緩激肽的酶活性來發(fā)揮作?，緩激肽促進(jìn)與HAE發(fā)作相關(guān)的腫脹和疼痛的主?物肽[1][2]。IC50&TargetPlasmakallikrein[1]REFERENCES[1].ZurawB,etal.Oralonce-dailyberotralstatforthepreventionofhereditaryangioedemaattacks:Arandomized,double-blind,placebo-controlledphase3trial[publishedonlineaheadofprint,2020Oct21].JAllergyClinImmunol.2020;S0091-6749(20)31484[2].ManningME,etal.Berotralstat(BCX7353)isanoveloralprophylactictreatmentforhereditaryangioedema:ReviewofphaseIIandIIIstudies.AllergyAsthmaProc.2021;42(4):274-282.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;