IM-54-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEIM-54Cat.No.:HY-108351CASNo.:861891-50-1分?式:C??H??N?O?分?量:325.4作?靶點(diǎn):Others作?通路:Others儲存?式:-20°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:50mg/mL(153.66mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.0731mL15.3657mL30.7314mL5mM0.6146mL3.0731mL6.1463mL10mM0.3073mL1.5366mL3.0731mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(7.68mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(7.68mM);Suspendedsolution;Needultrasonic1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性IM-54?種選擇性的氧化應(yīng)激誘導(dǎo)的壞死(necrosis)抑制劑。IM-54對H2O2誘導(dǎo)的壞死有強(qiáng)烈的抑制作?。IM-54?種潛在的?臟保護(hù)劑和研究細(xì)胞死亡分?機(jī)制的?物?具[1][2]。體外研究IM-54selectivelyinhibitsoxidativestress-inducednecrosis,butitdoesnotinhibitapoptosisinducedbyvariousanticancerdrugsorFasligand,ornecroptosis[1].IM-54showsstronginhibitionofH2O2-inducednecrosis,withanIC50of0.25μMinHL-60cells[1].REFERENCES[1].KosukeDodo,etal.IndolylmaleimideDerivativeIM-17ShowsCardioprotectiveEffectsinIschemia-ReperfusionInjury.ACSMedChemLett.2018Mar8;9(3):182-187.[2].MikikoSodeoka,etal.Developmentofselectiveinhibitorsofnecrosis.ChemRec.2010Oct;10(5):308-14.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37