E-Z-E64FC26-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(E/Z)-E64FC26Cat.No.:HY-122895ACASNo.:2285446-67-3分?式:C??H??F?O?分?量:340.38作?靶點(diǎn):Apoptosis作?通路:Apoptosis儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(293.79mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.9379mL14.6895mL29.3789mL5mM0.5876mL2.9379mL5.8758mL10mM0.2938mL1.4689mL2.9379mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(7.34mM);Suspendedsolution;Needultrasonic1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性(E/Z)-E64FC26E-E64FC26和Z-E64FC26的混合物。E64FC26(E-E64FC26)蛋?質(zhì)?硫鍵異構(gòu)酶(PDI)家族的?種有效的泛抑制劑，對(duì)PDIA1、PDIA3、PDIA4、TXNDC5和PDIA6的IC50分別為1.9、20.9、25.9、16.3和25.4μM。E64FC26顯?抗?髓瘤活性[1][2]。IC50&TargetPDI,Apoptosis[1][2]REFERENCES[1].NathanG.Dolloff,etal.Indenederivativesandusesthereof.US20190062298A1.[2].RobinsonRM,etal.Inhibitorsoftheproteindisulfideisomerasefamilyforthetreatmentofmultiplemyeloma.Leukemia.2019Apr;33(4):1011-1022.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>