專(zhuān)業(yè)選修課-《醫(yī)用生物工程進(jìn)展》課程教學(xué)大綱（英文班）

《Theprogressofmedicalbioengineering》syllabus

Classhours：36Credithours：2

CourseProperties：Professionalelectivecourse

Coursedepartment：Collegeofbiomedicine,HuaqiaoUniversity

Prerequisitecourses：AdvancedMathematics,GeneralPhysics,Microbiology,Genetics

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I

Thepropertyandtasksofthecourse

Theprogressofmedicalbioengineeringisoneoftheelectivecoursesofmedicalspecialtyinuniversities.Thiscourseisaspecializedelectivecoursethatstartsonthebasisofadvancedmathematics,generalphysics,microbiology,andgenetics.

Thiscoursefocusesonthecutting-edgeadvancesincontemporarymedicalbioengineeringresearch,enablingstudentstounderstandcurrentresearchprogressinthefieldoflifesciences,masteringrelevantconceptsandprinciples,andcultivatingstudents’interestinlifesciences.

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II

Teachingcontent

Thiscourseisintegratedinthelifesciencesandisaninterdisciplinarydisciplineofmedicine,lifesciences,andengineering.Itfocusesontheapplicationandresearchprogressofcontemporarybiotechnologyinthefieldofmedicine.

Thespecificcontentsareasfollows：

1IntroductiontoLifeScience

Itmainlyincludestheconcept,characteristics,mainresearchscope,developmenthistoryandresearchprogressoflifesciences.Sectionoftheresearchprogressismainlyincluded：Theintroductionofthehumangenomeprojectanditssignificance,theapplicationsandethicalissuesofgeneticengineeringtechnologyinmodernagricultureandmedicine,thediscoveryofpluripotentstemcellsandtheirsignificance,thesignificanceofsinglecellsequencingtechnologyandgeneeditingtechnology,etc.

1.Grasptheconcept,characteristicsandresearchscopeofMedicalBioengineering；2.Understandingthehistoryoflifescience；

3.Understandthecurrentprogressoflifescienceresearch,andfocusonunderstandingthesignificanceofiPScell,singlecellsequencingtechnologyandgeneeditingtechnology；

4.Understandtheresearchprogressofwell-knownscientistsinlifesciencesinChina.

2Progressintheresearchofgeneticengineeringdrugs

Theconceptofgeneticengineeringandgeneticengineeringdrugs,theclassification,characteristicsandactionprinciples,productiontechnologyandapplicationscopeofgeneticengineeringdrugs；

1.Grasptheconceptandmajorclassificationofgeneticengineeringdrugs；

2Learnthebasicflowofmonoclonalantibodyandvaccineproduction；

3.Understandtheroleandactionprincipleofcytokines；

4.Understandthebasicapproachforfindingdrugtargets；

5.Masterthemodificationandadministrationofgeneticallyengineereddrugs.

3MicroscopyImagingandAutophagy

Thedevelopmenthistoryofmicroscope,thecharacteristicsandexistencesignificanceofdifferenttypesofmicroscope,andtheapplicationofcryo-electronmicroscopyintoday'slifesciencesarereviewed，Theworkingprincipleandapplicationvalueofthe14yearNobelchemicalextendedresolutionfluorescencemicroscopy,theexistingproblemsinthesuper-resolutionfluorescencemicroscopeandthefuturedevelopmentdirection.Theconceptionofcellautophagy,thedistinctionandassociationbetweenapoptosis,necrosisandautophagy,themolecularmechanismandestablishmentprocessofautophagosomes,andthemethodsandcriteriaforthedetectionofautophagyinmodernbiology.

1.Knowtheimagecharacteristicsdisplayedbytypesmicroscopes,andidentifyingthesourceoftheinstrumentsusedaccordingtothepictures；

2.Understandtheapplicationofcryo-electronmicroscopyinlifesciencesandChinesescholars’contribution；

3.Grasptheworkingprincipleofsuper-resolutionfluorescencemicroscopeanditsfuturedevelopment；

4.Mastertheconceptofautophagyandtheformationprocessofautophagybodies,andunderstandthedifferenceanddetectionmethodsofapoptosis,necrosisandautophagy.

4CellTherapyinMedicine

Stemcellconcept,originandapplicationinmedicine,thedistinctbetweendifferenttypesofstemcells；Methods,existingsignificanceandethicalissuesofpluripotentinductionofstemcellculture；Theconceptanddevelopmentbackgroundofcellularimmunotherapy,theactionprincipleofimmunotherapyandthestatusquoathomeandabroad,thepracticalproblemsandsolutionsintheprocessofimmunotherapy.Theconceptofprecisionmedicaltreatmentanditsbackground,genomics,metabonomicsandtheconceptofmetagenomicsanditsapplicationinprecisionmedicine,thedevelopmentofprecisionmedicineathomeandabroad.

1.Understandtheconceptandclassificationofstemcells,aswellasthedifferenceandsimilaritiesbetweenstemcellsfromdifferentsources；

2.Understandthesignificanceofpluripotentstemcellinductionandmastertheprinciplesofpluripotentstemcellscreening；

3.Tounderstandtheconceptofcellimmunotherapyandthestatusofdevelopmentathomeandabroad,tograsptheprincipleofimmunotherapy,tounderstandtheexistingproblemsintheprocessofimmunotherapyandthefuturedevelopmentdirection；

4.Understandtheconceptanddevelopmentofprecisionmedicineathomeandabroad.

5AdvancesinLifeScienceResearch

Thischapterfocusesontheconcept,characteristics,methodsandprinciplesofsinglecellsequencing,imagingtechnologyinsmallanimals,photogeneticsandgeneediting,anditsapplicationinmedicine.

1.Understandthebasicconceptsandfeatures.

2.Understandtheoperationprocessandprinciplesofdifferenttechnologies,andknowtheapplicationvalueofdifferenttechnologiesinmedicine.

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III

Introductiontothekeyanddifficultpointsofthecourse

Chapter1LifeScienceIntroductionandDevelopment

Keypoint：

(1)Theconcept,characteristicsandresearchscopeofMedicalBioengineering；

(2)Frontierissuesinthefieldofcontemporarybiotechnologyresearch(stemcells,singlecellsequencingandgeneeditingtechnologies).

Difficultpoint：

(1)Theprincipleandapplicationofsinglecellsequencingtechnology；

(2)Thetypesanddifferencesofgeneeditingtechniques.

Chapter2Progressintheresearchofgeneticengineeringdrugs

Keypoint：

(1)Classificationofgeneticengineeringdrugs;

(2)Preparationoftherapeuticantibody；

(3)Thetypesandapplicationofvaccinesandmethodsofproduction;

(4)Theactingprincipleofdifferentcytokinedrugs;

(5)Searchingfornovelgeneengineeringdrugtargetsanddrugdeliveryroutes

Difficultpoint：

(1)Applicationofdifferentkindsofvaccines;

(2)Theprincipleofcytokinedrugaction;

(3)Thesearchfordrugtargets.

Chapter3Microimagingandautophagy

Keypoint：

(1)Theapplicationoftypesmicroscopes;

(2)The14thyearNobelPrizeinChemistryanditssignificance,theprincipleandapplicationofsuper-resolutionfluorescencemicroscopy;

(3)Theformationprocessofautophagybodiesduringautophagy;

(4)Thedifferencebetweenapoptosisandnecrosis.

Difficultpoint：

(1)Theprincipleofsuper-resolutionfluorescencemicroscopyimaging;

(2)Theprocessofcellautophagy.

Chapter4CellTherapyinMedicine

Keypoint：

(1)ThediscoveryandsignificanceoftheNobelprizeinmedicineinthepast12years,andtheprincipleofpluripotentstemcellinduction;

(2)Thetypes,methodsandprinciplesofcelltherapy;

（3）Backgroundandfuturedevelopmentofprecisionmedicine.

Difficultpoint：

(1)TheinductionprincipleofiPScells;

(2)Thetypesofcelltherapyandthedifferentprinciplesofaction.

Chapter5Advanceinfrontierresearch

Keypoint：Masteringtheoperationandapplicationofsinglecellsequencingtechnology,opticalgeneticstechnologyandgeneeditingtechnology.

Difficultpoint：Theprincipleofrelatedtechnologies.

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IV

Classhoursdistribution

Chapter

Classcontent

Classhour

Introduction

1

IntroductiontoLifeScience

4

Theconcept,characteristicsandresearchscopeofMedicalBioengineering

1

Thebackgroundandsignificanceofthehumangenomeproject

1

ApplicationofGeneticEngineeringinAgricultureandMedicine

1

AnoverviewofiPS,singlecellsequencingandgeneediting

1

2

Progressintheresearchofgeneticengineeringdrugs

8

Thespeciesandapplicationofgeneengineeringdrugs

1

Monoclonalantibodyandvaccinepreparation

2

Differentcytokinedrugs

2

Searchfortargetofgenedruganddrugmodification

2

Thewayofgeneengineeringdrugdelivery

1

3

Microimagingandautophagy

6

Thedevelopmenthistoryofmicroscopes

1

Cryopreservationandsuper-resolutionmicroscope

2

Autophagy

3

4

Theapplicationofcellimmunotherapy

8

Stemcelltypesandapplications

2

PrinciplesandMethodsofCellularImmunotherapy

2

ProblemsandSolutionsinImmunotherapy

1

Thebackgroundandprogressofprecisionmedicine

2

Genomics,Metabolomics,MetagenomicsandPrecisionMedicine

1

5

Frontierprogress

10

IntroductiontoResearchProgress

2

Progressandapplicationofsinglecellsequencingtechnology

2

Theprincipleandapplicationofimagingtechniqueinsmallani