Phycocyanobilin-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPhycocyanobilinCat.No.:HY-130750CASNo.:20298-86-6分?式:C??H??N?O?分?量:586.68作?靶點:ReactiveOxygenSpecies作?通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB儲存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實驗DMSO:<1mg/mL(ultrasonic;heatto60°C)(insolubleorslightlysoluble)請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性Phycocyanobilin?種具有?服活性的抗氧化劑(reactiveoxygenspecies)，?種有效的活性氧除劑。Phycocyanobilin可?于阿爾茨海默病的研究。體外研究Phycocyanobilin(100μM;0-250min)inhibitstheperoxidationofmethyllinoleateandproducesaprolongedinductionperiod[1].Phycocyanobilin(1mM;0-300min)suppressestheoxidationoftheliposomes[1].體內(nèi)研究Phycocyanobilin(15mg/kg;p.o.;indietfor2weeks)showsantioxidanteffectsintype2diabetesmice[3].AnimalModel:MaleC57BL/KsJdb/dbmice,arodentmodelfortype2diabetes[3]Dosage:15mg/kgAdministration:Indietfor2weeks1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEResult:Significantlydecreasedbloodglucoselevels.Normalizedtheincreasesinurinary8-OHdGand8-epi-PGF2αlevels,renaloxidativestressmarkersevaluatedbyrenal8-OHdGstainingandDHEstaining,Nox4mRNA,andproteinexpression,aswellasthemRNAlevelsofotherNAD(P)Hoxidasecomponents,inflammatorymarkersandHO-1.REFERENCES[1].HirataT,etal.AntioxidantactivitiesofphycocyanobilinpreparedfromSpirulinaplatensis.JournalofAppliedPhycology,2000,12:435-439.[2].MatamorosBP,etal.NutraceuticalandtherapeuticpotentialofPhycocyanobilinfortreatingAlzheimer'sdisease.JBiosci.2021;46:42.[3].ZhengJ,etal.PhycocyaninandphycocyanobilinfromSpirulinaplatensisprotectagainstdiabeticnephropathybyinhibitingoxidativestress.AmJPhysiolRegulIntegrCompPhysiol.2013Jan15;304(2):R110-20.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te