bPiDDB-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEbPiDDBCat.No.:HY-107674CASNo.:525596-66-1分?式:C??H??Br?N?分?量:514.38作?靶點:nAChR作?通路:MembraneTransporter/IonChannel;NeuronalSignaling儲存?式:Pureform-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(194.41mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.9441mL9.7204mL19.4409mL5mM0.3888mL1.9441mL3.8882mL10mM0.1944mL0.9720mL1.9441mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性bPiDDB?種有效的nAChR拮抗劑。bPiDDB(IC50=2nM)通過與含α6β2的nAChRs相互作?，抑制尼古丁誘發(fā)的紋狀體多巴胺(DA)的釋放。體內(nèi)研究bPiDDB(peripherallyadministered)inhibitsnicotine-evokeddopamine(DA)releaseinnucleusaccumbensanddecreaseintravenousnicotineself-administrationinrats[1].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEbPiDDBisbrainbioavailablefollowingperipheraladministrationandistransportedactivelybytheblood-brainbarriercholinetransporterintothecentralcompartment[1].REFERENCES[1].SmithAM,etal.RepeatednicotineadministrationrobustlyincreasesbPiDDBinhibitorypotencyatalpha6beta2-containingnicotinicreceptorsmediatingnicotine-evokeddopaminerelease.BiochemPharmacol.2010Aug1;80(3):402-9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: