DiscoveryBasedLearningUsingNMRSpectroscopy利用核磁共振光譜的學(xué)習(xí)為基礎(chǔ)的發(fā)現(xiàn)

DiscoveryBasedLearningUsingNMRSpectroscopy利用核磁共振光譜的學(xué)習(xí)為基礎(chǔ)的發(fā)現(xiàn)目前一頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)ProjectGoalsStudentGoalsImprove-Problemsolvingandcollaborativeskills-Abilitytoapplyexperimentaltechniquestosolveachemicalproblem.-Abilitytocommunicateresults(writtenandoral)CurricularGoalsImprovedlaboratoryexperienceBettersynergybetweenlectureandlaboratoryConnectionsbetweenchemistrycourses目前二頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)InvestigativeLaboratoriesStudentsdiscoverresultsinsteadofverifyingthemExperimentalprotocolsarelargelystudentdesignedWorkisdoneincollaborativegroupsInterpretationofresultsthroughdataanalysisGroupdiscussion目前三頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)ProjectPlanGradualismModel–stepwisepresentationofnewmaterialwithspecificgoalsInstrumentaltechniquesascommonthread -MolecularModeling -FTNMR(1Hand13C)ProjectbasedLaboratories–ReinforcesconceptsandskillsStudentinvolvementinlaboratorydesign目前四頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)FirstSemesterFocusesonTechniquesandInstrumentationDistillationCrystallizationMeltingpointTLCGCNMR目前五頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)SecondSemesterFocusesonApplicationNMRFT-IRMolecularmodelingStereochemistryandCouplingConstants目前六頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)Projectsshouldhaveclearlystated:ObjectiveOutcomeIntroductionTheoryfortheinstrumentationtobeusedbackgroundintothechemistryinvolvedExperimentalProcedure

目前七頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)1.34kcal/mol2.39kcal/mol目前八頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)EntryDihedralExpectedDihedralAngle(°)Expectedvalue(Hz)1HaxCCHeq602.52HaxCCHeq602.53HaxCCHax180124HaxCCHax18012EntryDihedralExpectedDihedralAngle(°)Expectedvalue(Hz)1HeqCCHeq602.52HeqCCHeq602.53HeqCCHax602.54HeqCCHax602.5目前九頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)目前十頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)ΨQuintetΨTripletofΨtriplets目前十一頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)Diels-AlderReactionpredictionofreactionproductcarryoutreactionusingpreviouslylearnedlabtechniquesAdaptedfrom:McDaniel,KeithF.;Weekley,R.Matthew“TheDiels-AlderReactionof2,4-Hexadien-1-olwithMaleicAnhydride:ANovelPreparationfortheUndergraduateOrganicChemistryLaboratoryCourse”J.Chem.Educ.

1997,74,1465.目前十二頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)StructureDeterminationNMRIRMechanisticexplanation目前十三頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)DihedralMeasuredAngleA(°)CalculatedJValueA(Hz)MeasuredAngleB(°)CalculatedJValueB(Hz)H1CCH218.938.42179.31

11.19H2CCH340.365.6153.33

3.64H3CCH445.284.8599.05

1.18an.su.se/ke3690/jhh.htmlprogramcalculates3JHHvaluesaccordingto:C.A.G.Haasnoot,F.A.A.M.DeLeeuwandC.AltonaTetrahedron

36(1980)2783-2792

目前十四頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)目前十五頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)H2H3H1DihedralMeasuredAngle(°)CalculatedJValueA(Hz)MeasureJValueA(Hz)H1CCH218.938.428.9H2CCH340.365.615.5H3CCH445.284.854.6目前十六頁(yè)\總數(shù)十七頁(yè)\編于十二點(diǎn)ElectronTransferSelfExch