中醫(yī)藥學循證醫(yī)學文獻閱讀

28八月2024中醫(yī)藥學循證醫(yī)學文獻閱讀記憶醫(yī)學術(shù)語方法之一NoChineseassimpleasoneword復(fù)雜學名記住中文即可中醫(yī)藥學循證醫(yī)學文獻閱讀GlossaryGinkgoBiloba

[5^iNk^Eu]

銀杏樹maidenhair[5meIdEnheE]

掌葉鐵線蕨intention-to-treatanalysis意向治療分析neurotransmitter[7njuErEtrAns5mitE]神經(jīng)遞質(zhì)bias[baiEs]prejudice偏見depression[di5preFEn]sadness沮喪抑郁tinnitus[ti5naitEs]

ringingintheears耳鳴viscosity[vis5kCsiti]stateofbeingthick粘性中醫(yī)藥學循證醫(yī)學文獻閱讀Ginkgo[5^iNk^Eu]中醫(yī)藥學循證醫(yī)學文獻閱讀maidenhair

掌葉鐵線蕨(少女秀發(fā)蕨)中醫(yī)藥學循證醫(yī)學文獻閱讀意向治療分析中醫(yī)藥學循證醫(yī)學文獻閱讀neurotransmitter[7njuErEtrAns5mitE]神經(jīng)遞質(zhì)中醫(yī)藥學循證醫(yī)學文獻閱讀Prejudice

偏見Bias[baiEs]中醫(yī)藥學循證醫(yī)學文獻閱讀Sadness抑郁Depression[di5preFEn]中醫(yī)藥學循證醫(yī)學文獻閱讀Ringingintheears耳鳴Tinnitus[ti5naitEs]中醫(yī)藥學循證醫(yī)學文獻閱讀Stateofbeingthick粘性viscosity[vis5kCsiti]中醫(yī)藥學循證醫(yī)學文獻閱讀記憶公共英語單詞方法之一NoChineseassimpleasonewordPlainEnglish（簡樸英語）中醫(yī)藥學循證醫(yī)學文獻閱讀Glossaryrobust[rE5bQst]strong精力充沛的substantive[5sQbstEntiv]large大量的cognitive[5kC^nitiv]

gettoknow認知的

modification[7mCdifi5keiFEn]makechange修正Unconfounded[kEn5faundid]notconfuse不糊涂的inconsistent[7inkEn5sistEnt]contradictory不一致中醫(yī)藥學循證醫(yī)學文獻閱讀Strong精力充沛的Robust[rE5bQst]中醫(yī)藥學循證醫(yī)學文獻閱讀Notconfuse不糊涂的Unconfounded[kEn5faundid]糊涂的

confounded[kEn5faundid]中醫(yī)藥學循證醫(yī)學文獻閱讀Contradictory不一致inconsistentshape[7inkEn5sistEnt]中醫(yī)藥學循證醫(yī)學文獻閱讀GlossaryGinkgoBiloba白果(中文即可)Maidenhair掌葉鐵線蕨(中文即可)Cognitivegettoknow

Substantive

largeAmendmentimproveDepressionsadnessTinnitusringingintheears

Viscositystateofbeingthick中醫(yī)藥學循證醫(yī)學文獻閱讀《醫(yī)學英語新教程》第30章-p234–閱讀16句子Ginkgo銀杏中醫(yī)藥學循證醫(yī)學文獻閱讀《醫(yī)學英語新教程》第30章-p234–閱讀16句子CochraneLibrary系統(tǒng)綜述文摘中醫(yī)藥學循證醫(yī)學文獻閱讀LearningObjectivesofSystematicReviewTomasterTitleAuthorStructureofSRResultConclusion

ToknowaboutIntroductionBackgroundObjectiveSearchstrategy掌握中醫(yī)藥學循證醫(yī)學文獻閱讀標題(十分簡潔)GinkgoBilobaforcognitiveimpairmentanddementia白果治療認知損害與癡呆癥（Cochrane系統(tǒng)綜述）掌握中醫(yī)藥學循證醫(yī)學文獻閱讀標題(十分簡潔)GinkgoBiloba

for

cognitiveimpairmentanddementia白果治療認知損害與癡呆癥（Cochrane系統(tǒng)綜述）掌握中醫(yī)藥學循證醫(yī)學文獻閱讀標題固定句式:中心詞＋for短語掌握中醫(yī)藥學循證醫(yī)學文獻閱讀當代(科技)醫(yī)學英語特點Controlledlanguage中醫(yī)藥學循證醫(yī)學文獻閱讀作者（≥2）BirksJGrimleyEvansJ掌握中醫(yī)藥學循證醫(yī)學文獻閱讀（Cochrane綜述文摘）CochraneReview‖SystematicReviewAbstract中醫(yī)藥學循證醫(yī)學文獻閱讀StructureofCochraneReveiwIntroductionBackgroundObjectiveSearchstrategySelectioncriteriaDatacollectionandanalysisMainresultsReview’sconclusion掌握中醫(yī)藥學循證醫(yī)學文獻閱讀StructureofCochraneReveiwIntroduction引言BackgroundObjectiveSearchstrategy檢索策略Selectioncriteria選擇標準Datacollectionandanalysis數(shù)據(jù)收集與分析Mainresults主要結(jié)果Review’sconclusion綜述者結(jié)論掌握中醫(yī)藥學循證醫(yī)學文獻閱讀引言(修訂,截至,被動)Asubstantive

amendmenttothissystematicreviewwaslastmadeon26August2002.此系統(tǒng)綜述的實質(zhì)性修改截止2002年8月26日。中醫(yī)藥學循證醫(yī)學文獻閱讀Background

origin起源currentstatus現(xiàn)況mechanism機制掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Background–originExtractsoftheleavesofthemaidenhairtree,Ginkgobiloba,havelongbeenusedinChinaasatraditionalmedicineforvariousdisordersofhealth.在中國，從掌葉鐵錢蕨白果樹葉精華作為傳統(tǒng)藥物，長期用于治療各種疾病。

掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Background–status②

Astandardizedextract

iswidely

prescribedinGermanyandFranceforthetreatmentofarangeofconditionsincludingmemoryandconcentrationproblems,confusion,depression,anxiety,dizziness,tinnitusandheadache.

掌握中醫(yī)藥學循證醫(yī)學文獻閱讀背景–現(xiàn)況②一種廣泛用于德國與法國的標準萃取物可治療多種疾病，包括記憶與思想集中病癥、意識模糊、抑郁、焦慮、頭暈、耳鳴與頭痛。

掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Background-mechanism③Themechanismsofactionarethoughttoreflecttheactionofseveralcomponentsoftheextractandincludeincreasing

bloodsupplybydilatingbloodvessels,reducingbloodviscosity,modificationofneurotransmittersystems,andreducingthedensityofoxygenfreeradicals.

掌握中醫(yī)藥學循證醫(yī)學文獻閱讀背景–機制③有人認為，若干成分的作用機制是擴張血管、降低血液粘滯度、改善神經(jīng)遞質(zhì)系統(tǒng)，以及減少氧游離基密度而增加血供

掌握中醫(yī)藥學循證醫(yī)學文獻閱讀3.Objective-explicit鮮明

Theaimofthereviewistoassesstheefficacyandsafety

ofGinkgobilobaforthetreatment

ofpatientswithdementiaorcognitivedecline.本綜述目標是評估白果治療癡呆癥或認知功能減退的有效性與安全性。

掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Searchstrategy–3T

TimeTypesTerms中醫(yī)藥學循證醫(yī)學文獻閱讀Strategy–Time&Types

Trialwereidentifiedon26June2002throughasearchoftheCDCIG……中醫(yī)藥學循證醫(yī)學文獻閱讀synonym同義詞&asterisk*

Thesearchtermsusedwereginkgo*,tanakan,EGB-761,EGB761and"EGB761".所用檢索術(shù)語為ginkgo*、tanakan、EGB-761、EGB761與“EGB761”。中醫(yī)藥學循證醫(yī)學文獻閱讀Selectioncriteria-phrase+clauseAllrelevant,unconfounded,

randomized,double-blindcontrolledstudies,inwhichextractsofGinkgobilobaatanystrengthandoveranyperiodwerecomparedwithplacebofortheir

effectsonpeoplewithacquiredcognitiveimpairment,includingdementia,ofanydegreeofseverity.中醫(yī)藥學循證醫(yī)學文獻閱讀收錄標準收錄所有與白果萃取物（任何濃度與任何療程）治療獲得性認知損害（包括任何類型的癡呆癥）相關(guān)的正規(guī)隨機雙盲安慰劑對照研究文獻。

中醫(yī)藥學循證醫(yī)學文獻閱讀collection&analysis-metaDataforthemeta-analysesarebasedonreportedsummarystatisticsforeachstudy.供薈粹分析分析的資料取自每個研究的發(fā)表總結(jié)性統(tǒng)計。

中醫(yī)藥學循證醫(yī)學文獻閱讀Mainresults–先總后分General:1-4Division(benefit):5-7

(thesamesentencepattern)Summary(adverse):8-9掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Mainresults–先總–概括Overall,thereare

nosignificantdifferencesbetweenGinkgoandplacebointheproportionofparticipantsexperiencingadverseevents.在總體上，接受白果與安慰劑受試者的不良反應(yīng)事件無顯著差異。

掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Mainresults–先總-metaThereare

benefits(主語)associatedwithGinkgo(doselessthan200mg/day)comparedwithplaceboatlessthan12weeks(54/63showedimprovementcomparedwith20/63,OR15.32,95%CI

5.90to39.80,P=<0.0001).掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Results–統(tǒng)計判斷掌握a/b效應(yīng)概率陽性數(shù)/總數(shù)-54/63OR(優(yōu)勢比)陽性概率/陰性概率小樣本-數(shù)越大，優(yōu)勢比大大樣本-數(shù)字小，優(yōu)勢比也大95%CI(可信區(qū)間)無零，數(shù)字大，顯著;5.9-39.8有零，≥0即顯著P值0.05>P>0.01顯著意義≤0.001極顯著意義中醫(yī)藥學循證醫(yī)學文獻閱讀Mainresults-先總-meta與安慰劑對照組相比，至少在12周以內(nèi)顯示白果（劑量>200mg/日）相關(guān)效益（56/43比20/63，優(yōu)勢比15.32，95%可信區(qū)間5.90至39.80，P=<0.0001）。

掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Mainresults–3divisionCognitionshows…(differentdata.)Activitiesshow…//.Measuresofmoodshow…//.Division–后分(療效)掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Mainresults–division-metaThereare

benefits(主語)associatedwithGinkgo(doselessthan200mg/day)comparedwithplaceboatlessthan12weeks(54/63showedimprovementcomparedwith20/63,OR15.32,95%CI5.90to39.80,P=<0.0001).掌握中醫(yī)藥學循證醫(yī)學文獻閱讀samepatternwithdifferentsubjectsanddataCognitionshowsbenefitforGinkgo(doselessthan200mg/day)comparedwithplaceboat12weeks(SMD-0.57,95%

CI-1.09,-0.05,P=0.03,randomeffectsmodel).

掌握中醫(yī)藥學循證醫(yī)學文獻閱讀samepatternwithdifferentsubjectsanddataActivitiesshowsbenefitforGinkgo(doselessthan200mg/day)comparedwithplaceboat12weeks(SMD-0.57,95%

CI-1.09,-0.05,

P=0.03,randomeffectsmodel).

掌握中醫(yī)藥學循證醫(yī)學文獻閱讀samepatternwithdifferentsubjectsanddataMeasuresofmood…showsbenefitforGinkgo(doselessthan200mg/day)comparedwithplaceboat12weeks(SMD-0.57,95%CI-1.09,-0.05,P=0.03,randomeffectsmodel).

掌握中醫(yī)藥學循證醫(yī)學文獻閱讀當代(科技)醫(yī)學英語特點Controlledlanguage中醫(yī)藥學循證醫(yī)學文獻閱讀Reviewers‘conclusionsMeritsImperfectProspect掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Reviewers‘conclusions–優(yōu)點Ginkgobilobaappearstobesafeinusewithno

excesssideeffectscomparedwithplacebo.應(yīng)用白果相對安慰劑無過度副作用，顯得(似乎)安全。掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Reviewers‘conclusions–說明Manyoftheearlytrialsusedunsatisfactorymethods,weresmall,andwecannot

excludepublicationbias.許多早期試驗應(yīng)用效果不滿意者多為小型研究,綜述者不能排除論文偏倚。掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Reviewers'conclusions-優(yōu)點Overallthereis

promisingevidenceofimprovementincognitionandfunctionassociatedwithGinkgo.總體上講，白果改善認知與功能依據(jù)前景良好。掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Reviewers‘conclusions–不足However,thethreemoremoderntrialsshow

inconsistentresults.然而，有３個以上當代臨床試驗的結(jié)果不一致。掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Reviewers’conclusions–展望Thereisneedforalargetrialusingmodernmethodologyandpermittinganintention-to-treatanalysistoproviderobustestimatesofthesizeandmechanismofanytreatmenteffects.尚需應(yīng)用現(xiàn)代的方法學與“意向治療分析”大型臨床試驗，以提供任何治療效應(yīng)大小的有力依據(jù)與機制。掌握中醫(yī)藥學循證醫(yī)學文獻閱讀Summary–keypointsTitle:干預(yù)+for+病癥Author:≥2,independently

StructureofSR:8