Itraconazole-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEItraconazole(Standard)Cat.No.:HY-17514RCASNo.:84625-61-6分子式:C??H??Cl?N?O?分子量:705.63作用靶點(diǎn):Fungal;Hedgehog;CytochromeP450;Autophagy;Antibiotic;Bacterial作用通路:Anti-infection;StemCell/Wnt;MetabolicEnzyme/Protease;Autophagy儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Itraconazole(Standard)是Itraconazole的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Itraconazole(R51211)是一種三唑類(lèi)抗真菌藥，也是一種有效的口服活性的Hedgehog信號(hào)通路拮抗劑，IC50約為800nM。Itraconazole可有效抑制羊毛甾醇14α-脫甲基酶(CytochromeP450)，從而抑制羊毛甾醇向麥角固醇的氧化轉(zhuǎn)化。Itraconazole具有抗癌和抗血管生成作用。Itraconazole也是一種oxysterol-bindingprotein(OSBP)抑制劑。IC50&TargetFungal[1]IC50:~800nM(Hedgehogsignalingpathway)[1]14α-demethylase(cytochromeP450enzyme)[3]REFERENCESKim,J.,etal.,Itraconazole,acommonlyusedantifungalthatinhibitsHedgehogpathwayactivityandcancergrowth.CancerCell,2010.17(4):p.388-99.Chong,C.R.,etal.,Inhibitionofangiogenesisbytheantifungaldrugitraconazole.ACSChemBiol,2007.2(4):p.263-70.PaceJR,etal.RepurposingtheClinicallyEfficaciousAntifungalAgentItraconazoleasanAnticancerChemotherapeutic.JMedChem.2016Apr28;59(8):3635-49.AlbulescuL,etal.Uncoveringoxysterol-bindingprotein(OSBP)asatargetoftheanti-enteroviralcompoundTTP-8307.AntiviralRes.2017;140:37-44.McePdfHeight1/1 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>