Jatrorrhizine-chloride-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEJatrorrhizinechloride(Standard)Cat.No.:HY-N0740RCASNo.:6681-15-8分?式:C??H??ClNO?分?量:373.83作?靶點(diǎn):Cholinesterase(ChE);5-HTReceptor;Bacterial作?通路:NeuronalSignaling;GPCR/GProtein;Anti-infection儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Jatrorrhizine(chloride)(Standard)Jatrorrhizine(chloride)的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Jatrorrhizinechloride從連中分離得到的?物堿，具有神經(jīng)保護(hù)、抗、抗瘧原?和抗氧化活性。Jatrorrhizinechloride有效的，具有?服活性的?酰膽堿酯酶(AChE)(IC50=872nM)的抑制劑，對(duì)BuChE的選擇性為115倍。Jatrorrhizinechloride通過抑制uptake-2transporter的活性減少?素(5-HT)和去甲腎上腺素(NE)的攝取。IC50&TargetIC50:872nM(AChE)[1]REFERENCES[1].SunS,etal.Jatrorrhizinereduces5-HTandNEuptakeviainhibitionofuptake-2transportersandproducesantidepressant-likeactioninmice.Xenobiotica.2019Oct;49(10):1237-1243.[2].XiaofeiJiang,etal.SynthesisandBiologicalEvaluationofNovelJatrorrhizineDerivativeswithAminoGroupsLinkedatthe3-PositionasInhibitorsofAcetylcholinesterase.ResearchArticleVolume2017[3].CWWright,etal.Invitroantiplasmodial,antiamoebic,andcytotoxicactivitiesofsomemonomericisoquinolinealkaloids.JNatProd.2000Dec;63(12):1638-40.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021