Salinomycin-sodium-salt-Standard-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemESalinomycinsodiumsalt(Standard)Cat.No.:HY-17439RCASNo.:55721-31-8分子式:C??H??NaO??分子量:772.98作用靶點:Wnt;β-catenin;Bacterial;Autophagy;Apoptosis;Antibiotic;Parasite作用通路:StemCell/Wnt;Anti-infection;Autophagy;Apoptosis儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Salinomycin(sodiumsalt)(Standard)是Salinomycin(sodiumsalt)的分析標準品。本產品用于研究及分析應用。Salinomycinsodiumsalt(Salinomycinsodium)，一種鉀離子載體抗生素，是Wnt/β-catenin信號傳導的有效抑制劑。Salinomycinsodiumsalt(Salinomycinsodium)作用于Wnt/Fzd/LRP復合物，阻斷Wnt誘導的LRP6磷酸化，導致LRP6蛋白降解。Salinomycinsodiumsalt(Salinomycinsodium)選擇性抑制人腫瘤干細胞。IC50&TargetWnt/β-catenin[1]REFERENCESLuD,etal.SalinomycininhibitsWntsignalingandselectivelyinducesapoptosisinchroniclymphocyticleukemiacells.ProcNatlAcadSciUSA.2011Aug9;108(32):13253-7.ZhouJ,etal.Salinomycininducesapoptosisincisplatin-resistantcolorectalcancercellsbyaccumulationofreactiveoxygenspecies.ToxicolLett.2013Oct24;222(2):139-45.KloseJ,etal.Salinomycin:Anti-tumoractivityinapre-clinicalcolorectalcancermodel.PLoSOne.2019Feb14;14(2):e0211916.WangF,etal.SalinomycinInhibitsProliferationandInducesApoptosisofHumanHepatocellularCarcinomaCellsInVitroandInVivo.PLoSOne.2012;7(12):e50638.QuH,etal.EffectofsalinomycinonmetastasisandinvasionofbladdercancercelllineT24.AsianPacJTropMed.2015Jul;8(7):578-82.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895