Shikonin-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEShikonin(Standard)Cat.No.:HY-N0822RCASNo.:517-89-5分?式:C??H??O?分?量:288.3作?靶點:ChlorideChannel;PyruvateKinase;NF-κB;TNFReceptor;HIV;AIM2作?通路:MembraneTransporter/IonChannel;Metabolic

Enzyme/Protease;NF-κB;Apoptosis;Anti-infection;

Immunology/Inflammation儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Shikonin(Standard)Shikonin的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Shikonin中草藥紫草的主要成分。Shikonin?種有效的TMEM16A氯化物通道(chloridechannel)抑制劑，IC50為6.5μM。ShikoninM2(PKM2)抑制劑，還可以抑制TNF-α和NF-κB途徑。Shikonin通過抑制糖酵解降低外泌體(exosome)的分泌。Shikonin抑制AIM2炎性體活化。IC50&TargetIC50:6.5μM(TMEM16Achloridechannel)[1]PKM2[2]TNF-α,NF-κB[3]REFERENCES[1].JiangYetal.ShikoninInhibitsIntestinalCalcium-ActivatedChlorideChannelsandPreventsRotaviralDiarrhea.FrontPharmacol.2016Aug23;7:270.[2].LiW,etal.ShikoninSuppressesSkinCarcinogenesisviaInhibitingCellProliferation.PLoSOne.2015May11;10(5):e0126459.[3].YanY,etal.ShikoninPromotesSkinCellProliferationandInhibitsNuclearFactor-κBTranslocationviaProteasomeInhibitionInVitro.ChinMedJ(Engl).2015Aug20;128(16):2228-33.[4].ZhangFY,etal.ShikoninInhibitstheMigrationandInvasionofHumanGlioblastomaCellsbyTargetingPhosphorylatedβ-CateninandPhosphorylatedPI3K/Akt:APotentialMechanismfortheAnti-GliomaEfficacyofaTraditionalChineseHerbalMedicine.IntJMolSci.2015Oct9;16(10):23823-48.[5].FuD,etal.ShikonininhibitsinflammationandchondrocyteapoptosisbyregulationofthePI3K/Aktsignalingpathwayinaratmodelofosteoarthritis.ExpTherMed.2016Oct;12(4):2735-2740.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[6].KathleenMMcAndrews,etal.Mechanismsassociatedwithbiogenesisofexosomesincancer.MolCancer.2019Mar30;18(1):52.[7].JernejZorman,etal.ShikoninSuppressesNLRP3andAIM2InflammasomesbyDirectInhibitionofCaspase-1.PLoSOne.2016Jul28;11(7):e0159826.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.T