Sumatriptan-succinate-Standard-GR-43175-succinate-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESumatriptansuccinate(Standard)Cat.No.:HY-B0121RCASNo.:103628-48-4Synonyms:GR43175succinate(Standard)分?式:C??H??N?O?S分?量:413.49作?靶點(diǎn):5-HTReceptor作?通路:GPCR/GProtein;NeuronalSignaling儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Sumatriptan(succinate)(Standard)Sumatriptan(succinate)的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Sumatriptansuccinate(GR43175)?種具有?服活性的5-HT1受體激動(dòng)劑，對(duì)5-HT1D、5-HT1B和5-HT1A受體的Ki分別為17nM、27nM和100nM。Sumatriptansuccinate可?于偏頭痛研究。體內(nèi)研究Sumatriptan(600μg/kg,i.p.or0.06μgin5μL,i.t.)reversesnitroglycerin-inducedthermalhypersensitivityinmice[4].?MolPharmacol.2023Nov;104(5):230-238.?PersonalizedMedicineUniverse.2019May.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].RazzaqueZ,etal.Vasoconstrictioninhumanisolatedmiddlemeningealarteries:determiningthecontributionof5-HT1B-and5-HT1F-receptoractivation.BrJClinPharmacol.1999Jan;47(1):75-82.[2].SJPeroutka,etal.Sumatriptan(GR43175)interactsselectivelywith5-HT1Band5-HT1Dbindingsites.EurJPharmacol.1989Apr12;163(1):133-6.[3].BatesEA,etal.Sumatriptanalleviatesnitroglycerin-inducedmechanicalandthermalallodyniainmice.Cephalalgia.20101/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEFeb;30(2):170-8.[4].KLDechant,etal.Sumatriptan.Areviewofitspharmacodynamicandpharmacokineticproperties,andtherapeuticefficacyintheacutetreatmentofmigraineandclusterheadache.Drugs.1992May;43(5):776-98.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-