TLR7-agonist-20-hydrochloride-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemETLR7agonist20hydrochlorideCat.No.:HY-158694A分?式:C??H??ClN?O分?量:396.91作?靶點(diǎn):Toll-likeReceptor(TLR)作?通路:Immunology/Inflammation儲(chǔ)存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:10mg/mL(25.19mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.5195mL12.5973mL25.1946mL5mM0.5039mL2.5195mL5.0389mL10mM0.2519mL1.2597mL2.5195mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性TLR7agonist20hydrochloride?種咪唑喹啉類(lèi)似物。TLR7agonist20hydrochloride?種有效的TLR7特異性激動(dòng)劑，對(duì)hTLR7的EC50值為0.23μM。TLR7agonist20hydrochloride對(duì)spike抗體?平表現(xiàn)出強(qiáng)效佐劑活性，可誘導(dǎo)強(qiáng)烈的T輔助細(xì)胞1(Th1)反應(yīng)，除IgG1外，IgG2b和IgG2c也增加。IC50&TargetTLR7TLR80.23μM(EC50)17.21μM(EC50)REFERENCES1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1].KaushikD,etal.Structure-ActivityRelationshipstowardtheIdentificationofaHigh-PotencySelectiveHumanToll-likeReceptor-7Agonist.JMedChem.2024May23;67(10):8346-8360.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-