GBR-12935-fumarate-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEGBR12935fumarateCat.No.:HY-12242BCASNo.:1349767-56-1分?式:C??H??N?O?分?量:530.65作?靶點(diǎn):DopamineTransporter作?通路:NeuronalSignaling儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性GBR12935fumarate?種有效的選擇性多巴胺再攝取抑制劑，在COS-7細(xì)胞中與多巴胺轉(zhuǎn)運(yùn)體的結(jié)合常數(shù)Kd為1.08nM。GBR12935fumarate對(duì)不同品系??的運(yùn)動(dòng)活性均有刺激作?，但對(duì)刻板印象?誘導(dǎo)作?。并且，GBR12935fumarate也可以防?d-芬氟拉明誘導(dǎo)的??頭抽搐反應(yīng)。REFERENCES[1].HiroiT,etal.Specificbindingof1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine(GBR-12935),aninhibitorofthedopaminetransporter,tohumanCYP2D6.BiochemPharmacol.1997Jun15;53(12):1937-9.[2].RahmanS,etal.NegativeinteractionofdopamineD2receptorantagonistsandGBR12909andGBR12935dopamineuptakeinhibitorsinthenucleusaccumbens.EurJPharmacol.2001Feb23;414(1):37-44.[3].TolliverBK,etal.ComparisonofcocaineandGBR12935:effectsonlocomotoractivityandstereotypyintwoinbredmousestrains.PharmacolBiochemBehav.1994Jul;48(3):733-9.[4].DarmaniNA.Cocaineandselectivemonoamineuptakeblockers(sertraline,nisoxetine,andGBR12935)preventthed-fenfluramine-inducedhead-twitchresponseinmice.PharmacolBiochemBehav.1998May;60(1):83-90.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02