Quercetin-d3-hydrate-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEQuercetin-d3hydrateCat.No.:HY-18085AS分?式:C??H?D?O?分?量:323.27作?靶點(diǎn):PI3K;Autophagy;Mitophagy;Apoptosis;ReactiveOxygenSpecies作?通路:PI3K/Akt/mTOR;Autophagy;Apoptosis;Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:30mg/mL(92.80mM;Needultrasonicandwarming)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.0934mL15.4669mL30.9339mL5mM0.6187mL3.0934mL6.1868mL10mM0.3093mL1.5467mL3.0934mLBIOLOGICALACTIVITY?物活性Quercetin-d3hydrate?種氘代的Quercetinhydrate(HY-18085A)，?種能刺激重組SIRT1的類酮，同時(shí)也?種PI3K抑制劑，其對(duì)PI3Kγ、PI3Kδ和PI3Kβ的IC50值分別為2.4μM、3.0μM和5.4μM[1]。IC50&TargetIC50:2.4±0.6μM(PI3Kγ),3.0±0.0μM(PI3Kδ),5.4±0.3μM(PI3Kβ)[1]體外研究Quercetinhydrateisatypeofplant-basedchemical,orphytochemical,usedasaningredientinsupplements,beveragesorfoods.Inseveralstudies,itmayhaveanti-inflammatoryandantioxidantproperties,anditisbeinginvestigatedforawiderangeofpotentialhealthbenefits.QuercetinhydrateisaPI3KinhibitorwithIC50of2.4-5.4μM.QuercetinhydratestronglyabrogatesPI3KandSrckinases,mildlyinhibitsAkt1/2,and1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEslightlyaffectedPKC,p38andERK1/2[1].QuercetinhydrateinhibitsTNF-inducedLDH%release,EC-dependentneutrophilsadhesiontobovinepulmonaryarteryendothelialcells(BPAEC),andBPAECDNAsynthesisandproliferation[2].體內(nèi)研究CombinationofQuercetinhydrate(75mg/kg)and2-MethoxyestradiolenhancesinhibitionofhumanprostatecancerLNCaPandPC-3cellsxenografttumorgrowth[3].REFERENCES[1].LeyreNavarro-Nú?ez,etal.Effectofquercetinonplateletspreadingoncollagenandfibrinogenandonmultipleplateletkinases.Fitoterapia.2010Mar;81(2):75-80.[2].YuXB,etal.InhibitoryeffectsofproteinkinaseCinhibitorsontumornecrosisfactorinducedbovinepulmonaryarteryendothelialcellinjuries.YaoXueXueBao.1996;31(3):176-81.[3].YangF,etal.CombinationofQuercetinand2-MethoxyestradiolEnhancesInhibitionofHumanProstateCancerLNCaPandPC-3CellsXenograftTumorGrowth.PLoSOne.2015May26;10(5):e0128277.[4].TaoLiu,etal.QuercetinalleviateskidneyfibrosisbyreducingrenaltubularepithelialcellsenescencethroughtheSIRT1/PINK1/mitophagyaxis.LifeSci.2020Jul20;118116.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Fo