TCGA癌癥數(shù)據(jù)庫(kù)介紹專題培訓(xùn)課件

目錄1TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025前言012TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025TCGA-theCancergenomeATLAS3TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025癌癥種類豐富，樣本量大34kindsofcancer325samplesonaverage4TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/20255TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/20256TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025數(shù)據(jù)產(chǎn)生歷程027TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025TCGA數(shù)據(jù)的產(chǎn)生歷程：1.組織樣本和臨床數(shù)據(jù)來(lái)源網(wǎng)站(TSS)收集的數(shù)據(jù)發(fā)送到Biospecimen核心資源(BCRs)。2.BCRs提交臨床數(shù)據(jù)和元數(shù)據(jù)到數(shù)據(jù)協(xié)調(diào)中心(DCC)和測(cè)序中心(GSCs),獲取組織變異數(shù)據(jù),然后提交給DCC。3.GSCs提交跟蹤文件,序列比對(duì)后文件到癌癥基因組學(xué)中心(CGHub)。4.提交給DCC和CGHub的數(shù)據(jù)可供研究團(tuán)隊(duì)和基因組數(shù)據(jù)分析中心(GDACs)使用。5.分析pipeline以及由GDACs產(chǎn)生的數(shù)據(jù)結(jié)果通過(guò)DCC保存到研究社區(qū)（community）中。http://8TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025barcode解讀039TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025詳細(xì)請(qǐng)見：/display/TCGA/TCGA+barcode10TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025DaTATYPESANDLEVELS0411TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025DATATYPES12TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025DataLevelLevelTypeDescription1RawLow-leveldataforsinglesample單個(gè)樣本的低級(jí)數(shù)據(jù)Notnormalized未標(biāo)準(zhǔn)化2ProcessedNormalizedsinglesampledata標(biāo)準(zhǔn)化的單個(gè)樣本Interpretedforpresenceorabsenceofspecificmolecularabnormalities解釋異常的個(gè)體3Segmented/InterpretedAggregateofprocesseddatafromsinglesample單個(gè)樣本整合在了一起Groupedbyprobedlocitoformlargercontiguousregions(insomecases)根據(jù)probe的位置分組4Summary/RegionsofInterest(ROI)Quantifiedassociationacrossclassesofsamples量化關(guān)聯(lián)類的樣本Associationsbasedontwoormore兩個(gè)或多個(gè)的關(guān)聯(lián)Molecularabnormalities分子水平的異常Samplecharacteristics樣本特性Clinicalvariables臨床變異DATALEVLES13TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025注意：低水平的測(cè)序數(shù)據(jù)存儲(chǔ)在CGHub,申請(qǐng)下載時(shí)需要DUNSnumber.TheCancerGenomicsHub(CGHub)isasecurerepositoryforstoring,cataloging,andaccessingcancergenomesequences,alignments,andmutationinformationfromtheCancerGenomeAtlas(TCGA)consortiumandrelatedprojects.14TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025目前已有的癌癥種類0515TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025癌癥種類豐富，樣本量大34kindsofcancer325samplesonaverage16TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025詳細(xì)見：TCGApublicationguideline,17TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025數(shù)據(jù)下載及解讀0618TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/202519TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/202520TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/202521TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025

最簡(jiǎn)單的方法：22TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/202523TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/202524TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025

第1封郵件通知下載申請(qǐng)已經(jīng)提交第2封給出下載鏈接Step425TCGA癌癥數(shù)據(jù)庫(kù)介紹專題1/22/2025Step4文件內(nèi)容File_manifest.txt，對(duì)所下載文件的說(shuō)明26TCGA癌