Ketotifen-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEKetotifen(Standard)Cat.No.:HY-B0157RCASNo.:34580-13-7分子式:C??H??NOS分子量:309.43作用靶點(diǎn):EndogenousMetabolite;HistamineReceptor;SARS-CoV;InfluenzaVirus作用通路:MetabolicEnzyme/Protease;GPCR/GProtein;Immunology/Inflammation;NeuronalSignaling;Anti-infection儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Ketotifen(Standard)是Ketotifen的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Ketotifen(HC20-511)是一種具有口服活性的第二代非競(jìng)爭(zhēng)性組胺1(H1)受體阻滯劑和肥大細(xì)胞穩(wěn)定劑。Ketotifen可在體外阻斷6-磷酸葡萄糖酸脫氫酶(6-PGD)。Ketotifen還對(duì)SARS-CoV-2和流感病毒(Influenzavirus)具有抗病毒活性。Ketotifen可用于自身免疫性腦脊髓炎(EAIC50&TargetHistamine1,SARS-CoV-2,Influenzavirus[1][3][4]REFERENCESKlookerTK,etal.Themastcellstabiliserketotifendecreasesvisceralhypersensitivityandimprovesintestinalsymptomsinpatientswithirritablebowelsyndrome.Gut.2010Sep;59(9):1213-21.ZhangH,etal.Advancesinthediscoveryofexosomeinhibitorsincancer.JEnzymeInhibMedChem.2020;35(1):1322-1330.KianiP,etal.InVitroAssessmentoftheAntiviralActivityofKetotifen,IndomethacinandNaproxen,AloneandinCombination,againstSARS-CoV-2.Viruses.2021Mar26;13(4):558.EnkirchT,etal.IdentificationandinvivoEfficacyAssessmentofApprovedOrallyBioavailableHumanHostProtein-TargetingDrugsWithBroadAnti-influenzaAActivity.FrontImmunol.2019Jun5;10:1097.PinkeKH,etal.CalmingDownMastCellswithKetotifen:APotentialStrategyforMultipleSclerosisTherapy?Neurotherapeutics.2020Jan;17(1):218-234.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58